MedChemWatch
Monthly Newsletter May 2016

EFMC-ISMC 2016 - XXIV EFMC International Symposium on Medicinal Chemistry, August 28 - September 1, 2016, Manchester, UK

EFMC-ISMC 2016 will cover drug discovery advances in major therapeutic areas, including the treatment of pain, CNS disorders, anti-infectives, ophthalmology, cardiovascular diseases and oncology. The most recent advances in lead identification and optimization strategies, drug design and profiling technologies will be presented. The impact of biomarkers and imaging at the interfaces between chemistry, biology and experimental medicine will be illustrated. Particular emphasis will be put on first time disclosures, recent highlights in medicinal chemistry and the impact of novel organic synthesis in drug discovery.

Find out more about:

CALL FOR ABSTRACTS FOR POSTERS - FINAL DEADLINE IS JUNE 16

Abstracts for poster presentations can be submitted until June 16. Since the deadline for free abstract submissions has passed since March 23, submissions will be charged 50€ for additional handling costs.

 
3rd EFMC YOUNG MEDICINAL CHEMIST SYMPOSIUM | SEPTEMBER 1-2, 2016

In connection with EFMC-ISMC 2016, the EFMC organises the third edition of the EFMC Young Medicinal Chemist Symposium which will take place on September 1-2 at the Manchester Institute of Biotechnology (University of Manchester). This Symposium is open to any scientist interested by the topics related to Medicinal Chemistry.

Due to this connection, the participants registered to EFMC-ISMC 2016 can benefit from a special rate for their participation in EFMC-YMCS 2016, and students can register for free!

More information and registration are available on the EFMC-YMCS website.


ENJOY MANCHESTER!

Manchester

Manchester is a city of radical thinking, inspirational science and world changing first - it is the city where Rutherford first split the atom and Rolls met Royce, it is the home of the first passenger railway station and programmable computer. Manchester now holds claim to another first, in being awarded the European City of Science 2016. This award comes as recognition of its unique scientific heritage and contribution to scientific discovery, innovation and industry. The city has been at the forefront of scientific innovation since the Industrial Revolution through to the modern age.

The city of Manchester is the third-most visited city in the UK by foreign visitors, after London and Edinburgh. It is notable for its architecture, culture, musical exports, sports clubs and transport connections. Its city centre mixes historic and new architecture rather well, ranging from Victorian to contemporary architecture. The widespread use of red brick characterises the city which has over 135 parks, gardens, and open spaces.

The city is home to a number of museums, among which the Museum of Science & Industry, highlighting Manchester's key role in the Industrial Revolution, and the Manchester Art Gallery, the city's top gallery displaying a superb collection of British art. In Manchester you will of course also find one of the world’s most famous football clubs – Manchester United, as well as top Premier League club Manchester City!

Read more about Manchester on the Visit Manchester website.


Find out more on: www.efmc-ismc.org

RICT 2016 - Interfacing Chemical Biology and Drug Discovery, July 6-8, 2016, Caen, France

The French Medicinal Chemistry Society (Société de Chimie Thérapeutique - SCT) is pleased to invite you to Caen (Normandy), France on July 6-8, 2016 for the 52nd edition of the International Conference on Medicinal Chemistry (RICT 2016).

Patrick Dallemagne, head of the Local Organising Committee will welcome you in the city of William the Conqueror, Duke of Normandy and King of England.

The congress will be devoted to Interfacing Chemical Biology and Drug Discovery and the main topics will be:

  • Approaches for Target Identification-Validation
  • Biomarkers – Innovative Diagnostic Approaches, Tools
  • Molecular Diversity
  • Chemoinformatics in and for Drug Discovery
  • Therapeutic Interventions Targeting the Nervous System
  • Case Studies (all targets and therapeutic indications included)

Additionally you will be able to appreciate the climate of the beautiful Normandy and visit the famous Mont-Saint-Michel, its wild coast with its lighthouses, the D-Day historic sites and beaches, the green countryside (here the highland named Norman Switzerland) or the lovely Alabaster seaside with the famous Etretat beach.
 
Caen is located at 230 kilometers from Paris and easily accessible by car, train, plane or even by boat (Caen - Ouistreham harbour).

Find out more on www.rict2016.org

1st Medicinal Chemistry Ireland Conference, July 1st, 2016, Dublin, Ireland

The Pharmaceutical and Medicinal sectors are of enormous importance for the Irish economy. Academic and industrial research and development in this area will sustain Ireland’s position and as a key player in the global landscape.

We would like to launch the 1st Medicinal Chemistry Ireland Conference in Ireland, a one-day event which will be held in the Trinity Biomedical Sciences Institute (Trinity College Dublin) on July 1st, 2016. This meeting will bring together some of the most relevant researchers in the field, both from industry and academia.

SPEAKERS

The following distinguished researchers will take part:

  • Prof. Christopher McGuigan (Cardiff University, Wales; Pharmacy)
    “ProTides: Dragging Nucleotides into Cells, and All the Way from the Lab Bench to Clinical Use”

  • Prof. Francesco Peri (University Milano Bicoca, Italy; Chemistry)
    “Toll-Like Receptor Activation and Function in Health and Disease: an Integrated Chemical-Biology Approach”

  • Prof. Carmen Galan (University of Bristol; Chemistry)
    “Novel Synthetic Glyco-Tools for Drug Discovery”

  • Dr. Simon Macdonald (Director of Medicinal Chemistry, GSK, Stevenage, UK)
    “Integrin Antagonists for Fibrotic Diseases”

  • Prof. Mari-Luz Lopez-Rodriguez (Universidad Complutense de Madrid; Chemistry)
    “Chemistry for Drug Target Identification and Validation”

  • Prof. Mary Meegan (Trinity College Dublin; Pharmacy)
    “Biological Evaluation in vitro of Azetidin-2-one Derivatives as Potential Anti-Cancer Agents”

 Find out more on https://medchemmeet.wordpress.com/

ESMEC - European School of Medicinal Chemistry – Urbino June 26 - July 1, 2016 Urbino, Italy

The mission of the ESMEC is to provide participants, PhD students and junior researchers from both academia and industry, with the most recent advances in the field of medicinal and organic chemistry, pharmacology, molecular biology and analytical/ structural chemistry.

This idea is aimed to reflect the current scenario of medicinal chemistry being a truly transdisciplinary approach, where the advances in knowledge are driven by the medicinal chemist’s ability to translate into new molecular concepts and into novel molecular entities the amount of information created by molecular medicine, pharmacology, molecular biology, systems biology.

For these reasons, the School is directed to participants at a graduated and post-graduated level, in chemistry but also in pharmacology or biology, who are keen to explore the interdisciplinary context of current cutting-edge research in medicinal chemistry. To achieve these very ambitious goals, the School is organised into thematic sessions, each of them constructed around a series of lectures, followed by practical workshops.

Find out more on http://www.esmec.eu/

Official report on the STOA Working Breakfast on Solving Antibiotic Resistance

During the STOA Working Breakfast co-organised by the European Parliament´s STOA, EuCheMS, and EFMC on the 28 April 2016, researchers and several Members of the European Parliament analysed the global challenge of antimicrobial resistance and weighted the pros and cons of possible solutions.

Read the full report on the EFMC Website.

EFMC Awards

The EFMC is pleased to announce the recipients of the 2016 Awards!

Nauta Award for Pharmacochemistry
Prof. François Diederich – ETH Zürich, Switzerland

For his outstanding contributions to the science of medicinal chemistry. Prof. François Diederich made essential contributions to the fundamental understanding of non-bonding interactions involved in molecular recognition and their application in modern drug design. His scientific work is documented in more than 700 publications and beautifully describes interactions such as sulfur-aromatics, cation-Pi, fluorine interactions and halogen bonding that are actively used by many scientists around the world in the discovery of novel drugs.

UCB-Ehrlich Award for Excellence in Medicinal Chemistry
Prof. Paul J. Hergenrother – University of Illinois at Urbana-Champaign, United States

For his groundbreaking work on procaspase-3 activation by a small molecule PAC-1, thereby inducing apoptosis in cancer cells. In his scientific research he uses natural products as starting points for complex molecule synthesis in an approach named “complexity-to-diversity”.  Next to basic research, he also aims to bring his novel compounds to the clinic for the benefit of patients.

Prous Institute-Overton and Meyer Award for New Technologies in Drug Discovery
Prof. Jan Steyaert – VIB & VU Brussels, Belgium

For his pioneering work in the field of nanobody-enabled structural biology. His nanobody technology led to X-ray crystallographic structures of GPCRs locked in an agonist-bound active conformational state and to the first view of a GPCR transmembrane signalling complex. These novel GPCR structures are now finding widespread use in the discovery of novel drugs.

The Awards will be presented during the XXIV International Symposium on Medicinal Chemistry (EFMC-ISMC 2016), scheduled to be held on August 28 – September 1, 2016 in Manchester, United Kingdom.

 

EFMC ORGANISED EVENTS

September 6-7, 2018
Ljubljana, Slovenia
5th EFMC Young Medicinal Chemist Symposium (EFMC-YMCS 2018)

EFMC SPONSORED EVENTS

January 28 - February 1, 2018
St Anton, Austria
1st Alpine Conference on Medicinal and Synthetic Chemistry

JOB PORTAL

Early Stage Researcher in Medicinal Chemistry, University of Basel (UNIBAS), University of Utrecht (UU), PamGene: Department of Pharmaceutical Sciences (UNIBAS), Department of Chemical Biology & Drug Discovery (UU), Basel, Utrecht, 's-Hertogenbosch, Switzerland
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Early Stage Researcher in Medicinal Chemistry, University of Ljubljana (UL), University of Utrecht (UU), PamGene: Faculty of Pharmacy, Chair of Pharmaceutical Chemistry (UL), Department of Chemical Biology & Drug Discovery (UU), Ljubljana, Utrecht, 's-Hertogenbosch, Slovenia
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Early Stage Researcher in Medicinal Chemistry, University of Utrecht (UU), University of Ljubljana (UL), PamGene: Department of Chemical Biology & Drug Discovery (UU), Faculty of Pharmacy, Chair of Pharmaceutical Chemistry (UL), Utrecht, Ljubljana, 's-Hertogenbosch, The Netherlands
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Early Stage Researcher in Medicinal Chemistry, University of Basel (UNIBAS), University of Ljubljana (UL): Department of Pharmaceutical Sciences (UNIBAS), Faculty of Pharmacy, Chair of Pharmaceutical Chemistry (UL), Basel, Ljubljana, Switzerland
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Early Stage Researcher in Medicinal Chemistry, University of Ljubljana (UL), Lund University (ULUND), SARomics, Red Glead: Faculty of Pharmacy, Chair of Pharmaceutical Chemistry (UL), Department of Chemistry (ULUND), Ljubljana, Slovenia
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Early Stage Researcher in Medicinal Chemistry, Università degli Studi di Milano (UMIL), Universiteit Utrecht (UU), PamGene: Chemistry (UMIL), Department of Chemical Biology & Drug Discovery (UU), Milano, Utrecht, 's-Hertogenbosch, Italy
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Early Stage Researcher in Medicinal Chemistry, Università degli Studi di Milano (UMIL), Université Grenoble Alpes (UGA), Centre national de la recherche scientifique (CNRS-Glycopedia): Chemistry (UMIL), CERMAV (UGA), Milano, Gières, Grenoble, Italy
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Early Stage Researcher in Medicinal Chemistry, Université Grenoble Alpes (UGA), Universiteit Utrecht (UU), PamGene: CERMAV (UGA), Department of Chenical Biology & Drug Discovery (UU), Gières, Utrecht, 's-Hertogenbosch, France
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Early Stage Researcher in Medicinal Chemistry, Universiteit Utrecht (UU), Université Grenoble Alpes (UGA), Centre national de la recherche scientifique (CNRS): Department of Chemical Biology & Drug Discovery (UU), CERMAV (UGA), Utrecht, Gières, Grenoble, The Netherlands 
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Early Stage Researcher in Medicinal Chemistry Université Grenoble Alpes (UGA), Università degli Studi di Milano (UMIL), Centre national de la recherche scientifique (CNRS) : CERMAV (UGA), Department of Chemistry (UMIL), Gières, Milano, Grenoble, France
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Research / Senior Scientist Medicinal Chemistry, UCB: Medicinal Chemistry, Braine-L'Alleud, Belgium
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Principal Scientist Medicinal Chemistry, UCB: Medicinal Chemistry, Braine-L'Alleud, Belgium
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Medicinal / Synthetic Organic Chemists, Concept Life Sciences: Drug Discovery, Sandwich, Kent, United Kingdom
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