HAPPY 50th ANNIVERSARY EFMC!
It is now official, our EFMC Historians (Prof. Henk Timmerman & Dr Edmond Differding) can trace the exact moment of creation of the European Federation for Medicinal Chemistry. The date was 19th December 1969, and it was during a scientific meeting in Paris. The rest, as they say, is history.
We will be celebrating our first 50 years throughout 2020. Keep your eyes on MedChemWatch, our social media outlets and events for further news. However, in the meantime, we are proud to unveil our new logo:
CALL FOR NOMINATIONS – EFMC-YSN PhD PRIZE!
Recognizing excellence has always been a priority for EFMC. We are, therefore, proud to join the Young Scientists Network in announcing the first "EFMC-YSN PhD Prize".
The Prize will consist of a diploma, a free registration and a 500€ travel grant to attend the XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2020) and EFMC Young Medicinal Chemist Symposium (EFMC-YMCS 2020) which will take place in Basel, Switzerland on September 6-10 & 10-11, 2020.
Who can apply?
• European PhD students (and up to one year after PhD)
• Abstract of the poster to be presented at the EFMC-ISMC 2020 & EFMC-YMCS 2020
• List of publications
• Cover letter: « Why is my research worth the Prize »
How to apply?
• Via the online form
Deadline for submission: January 31, 2020
The winner will be announced during the month of April.
EFMC GRANTS APPLICATIONS ARE OPEN!
EFMC is funding grants for EFMC organised events with the aim to support the participation of young academic scientists.
Upon application, a limited number of grants will be covered by EFMC, corresponding to:
• The full registration fees for EFMC-ISMC
• Up to 50% of the registration fees for the EFMC Short Courses
Please be informed that following new EFMC regulations, only the members of an EFMC National Adhering Organisation will be allowed to apply for the EFMC grants.
EFMC Grants are available for the following events:
• 16th EFMC Short Course on Medicinal Chemistry - New Opportunities in GPCR Drug Discovery
May 17-20, 2020 - Oegstgeest, The Netherlands
Deadline for application: March 1, 2020
• XXVI EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2020)
September 6-10, 2020 - Basel, Switzerland
Deadline for application: April 2, 2020
• 7th EFMC Young Medicinal Chemist Symposium (EFMC-YMCS 2020)
September 10-11, 2020 - Basel, Switzerland
Combined with the grant application of EFMC-ISMC 2020
(Participation to both events is required)
Important remark: A grant application does not automatically register you to the conference. If your grant application is accepted, you will have to register to the conference, and submit your abstract again. If you wish to be considered for an Oral Communication at the EFMC-ISMC, you will have to register to the conference before April 2. In case your grant application is refused, free cancelation will be allowed.
GET TO KNOW MICHAL SHOSHAN (UNIVERSITY OF ZURICH, SWITZERLAND)
In this newsletter, we invite you to learn more about Dr Michal Shoshan, the winner of the Presentation Prize at the EFMC Young Medicinal Chemist Symposium 2019. She will be invited to deliver an Oral Communication at the EFMC-ISMC 2020 in Basel, Switzerland.
How did you get interested in Medicinal Chemistry?
I was always attracted to applicable chemistry that can positively affect the lives of many. During my whole training the medicinal potential of my research was constantly motivating me to further explore and investigate.
Where and when did you obtain your PhD diploma?
I graduated at the Hebrew University of Jerusalem in 2015.
What was the topic of your PhD project?
Mimetic Peptides of Copper Metallochaperones: Structural Characterization and Potential Treatment for Copper Homeostasis Disorders.
Where did you have your postdoc position?
At the lab of Prof. Dr. Helma Wennemers at ETH Zurich.
Where do you work at the moment and what is your current position?
I am an independent group leader at the University of Zurich.
What are your current research interests?
Selective detoxification of various toxins including metals, peptides and small molecules.
What do you like most in your job?
Coming up with new research ideas, designing experiments and potential molecules, mentoring students.
What kind of tasks your job includes?
Managing research projects of BSc, MSc and PhD students, papers and research proposals writing, teaching.
What kind of skills your job requires?
Creativity, management skills, analytical skills.
What do you consider your biggest achievement in your scientific career?
Opening my independent group that is being supported by the Swiss National Science Foundation.
What are the features of a successful PhD student or postdoc?
Diligence, independence, creativity, consistency.
How would you describe yourself as a supervisor?
I care about the progress of my students and try to push them as much as I can for success. I encourage them for an independent thinking. I believe that a student that knows the bigger picture is more motivated to accomplish her/his goals and therefore I constantly share with my students the primary goals and future directions so they could choose where to take their projects to.
What is the most embarrassing thing you did in the lab while doing experiments?
I drained a GPC column that is extremely expensive but I was lucky that my colleague could save it...
Which scientist do you admire the most and why?
I admire scientists that are shiny with their brilliant and creative minds, and moreover, the ones that are modest regarding their outstanding achievements, for example Jorn Piel from ETH and Luisa de Cola from the University of Strasbourg.
Did you experience any unfair situations during your scientific career?
I guess there were situations that could have been unfair but I try not to think about the things I didn’t get (and why) and focus and appreciate the things I accomplished.
Which paper of yours you are the proudest of and why?
My last paper at Angew. Chemie (2019) since it was a project that I designed from scratch and saw it evolving step-by-step. It was a pleasure to deal with the challenges of each of these steps and to finally have this incredible outcome.
Which field of medicinal chemistry do you consider the most promising in the future?
I think that peptides as pharmaceuticals still didn’t show us their whole potential. And although the number of peptide-based drugs is constantly raising, I think that many more of them can be developed and replace either proteins or small molecules.
What would you guess to be the next major breakthrough in medicinal chemistry?
Personalized therapy based on machine learning.
REGISTRATIONS FOR THE EFMC SHORT COURSE ON NEW OPPORTUNITIES IN GPCR DRUG DISCOVERY
Scheduled to take place on May 17-20, 2020 in Oegstgeest (near Leiden), The Netherlands, this intensive 3-day course will be given by expert in the field of GPCRs (check the programme).
G-protein coupled receptors represent the largest class of drug targets. Although they serve as targets for about 30% of the known drugs, many of them is still orphan. In the last 15 years, however, we witnessed dramatic developments in the structural biology and pharmacology of GPCRs. High resolution X-ray and cryo-EM structures made the design of the GPCR ligands more rational. The widening knowledge on their signalling resulted in new concepts such as allosteric modulation, GPCR residence time and biased signalling currently tested in clinical trials. This course will provide an introduction for medicinal chemists to this important target class including concepts and methods applied in the structural biology, modelling, systems biology, pharmacology and medicinal chemistry of GPCRs. The course will finish with a series of medicinal chemistry case studies, including the discovery of molecular probes, tool compounds, clinical candidates and marketed drugs.
György Miklós KESERÜ (Research Centre for Natural Sciences, Hungarian Academy of Sciences, Hungary)
Rob LEURS (VU University Amsterdam, The Netherlands)
Henk TIMMERMAN (VU University Amsterdam, The Netherlands)
Laura HEITMAN (University of Leiden, The Netherlands)
Register now! - Places are limited.
REPORT OF THE ICBS 2019 ANNUAL MEETING
The event took place on 2-4 November at the Council for Scientific & Industrial Reseach’s Indian Institute of Chemical Technology (CSIR-IICT), Hyderabad, India. The theme was “Navigating Translational Discoveries”, and the event was a great success – with about 300 participants and 113 posters.
The EFMC session on “Cancer and checkpoint inhibitors” was well received. The talks from Murali Ramachandra (Aurigene), Maria Duca (Uni Nice-Côte d’Azur), Dhanalakshmi Sivanandhan (Jubilant) and Pradip Nair (Biocon) were well attended and very interesting and of a good quality.
The EFMC thanks all the speakers, and particularly Dr Edmond Differding for his help in putting the programme together.
2020 INTERNATIONAL SYMPOSIUM ON CHEMICAL BIOLOGY (REGISTRATION DEADLINE IS 16th DECEMBER 2019)
NCCR Chemical Biology is pleased to announce the third edition of the International Symposium on Chemical Biology. The event will take place on January 22 to 24, 2020 at the Campus Biotech, Geneva, Switzerland.
This major international event in the field of chemical biology will bring together leading scientists, comprising two keynote speakers (Prof. Laura Kiessling (MIT) and Prof. Giulio Superti-Furga (CeMM)) and thirteen outstanding speakers who will collectively cover topics around the engineering of proteins and small molecules, chemogenetic and optogenetic technologies for probing molecular and cellular interactions, technologies to probe active molecules in their native environment, etc.
The aim of this international event is to learn more about the latest advances in the field of chemical biology and to foster an open and dynamic dialogue amongst the scientists conducting this exciting research.
Registration deadline is 16th December 2019.
Fee waiver/travel grant fellowships are available. The event will also include a Poster & Young researcher prize session.
Full details can be found on the symposium website: http://symposium.nccr-chembio.ch/
‘FRONTIERS IN MEDICINAL CHEMISTRY’ WITH CHEMICAL EPIGENETICS SESSION ORGANISED BY THE GERMAN MEDICINAL CHEMISTRY DIVISIONS OF GDCH AND DPHG
The German Chemical Society (GDCh) and the German Pharmaceutical Society (DPhG) cordially invite you to participate in the annual meeting on 'Frontiers in Medicinal Chemistry´ March 22-25, 2020, Freiburg, followed by the 3rd Chemical Epigenetics Meeting, March 25-27.
The international symposium will focus on current developments, novel approaches and cutting-edge technologies in the field of medicinal chemistry and drug research with sessions on Chemical Proteomics – Activity based Protein Profiling, Macrocyclic and Covalent Inhibitors, Young Investigators, Novel Computational Methods, Epigenetics, and Highlights in Medicinal Chemistry and Case Studies. The scientific program will include lectures and poster presentations. It is the goal of the organizers to make this meeting an event of scientific excellence, attractive to both industrial and academic scientists in Medicinal Chemistry, Chemical Biology, and related fields of research. The Frontiers of Medicinal Chemistry Conference is followed by the 3rd Chemical Epigenetics Meeting, March 25-27, 2020.
More information: https://veranstaltungen.gdch.de
NEWS OF THE FRENCH SOCIETY OF MEDICINAL CHEMISTRY (SCT) - YRFM YOUNG RESEARCH FELLOWS MEETING (JANUARY 29-31, 2020)
The YRFM Young Research Fellows Meeting is an initiative of the French Medicinal Chemistry Society (SCT).
This meeting brings together young European scientists (PhD students, post-doctoral fellows and young academic/industrial confirmed researchers) and gives them the opportunity to present and discuss the latest innovations and future trends in Medicinal Chemistry.
The topics will cover all aspects of research in medicinal chemistry: the research and validation of biological targets of therapeutic interest, screening, design, optimization and selection of drug candidates, chemical biology, medicinal chemistry, pharmacokinetics, metabolism and toxicity (ADME-T: absorption, distribution, metabolism, excretion, toxicity).
Registration deadline is December 20 !
Many prestigious prizes will be attributed (SCT, ACS, EFMC, MDPI) for best oral communications, and posters.
CONFIRMED PLENARY LECTURES
- Andrew Sutherland (University of Glasgow, Scotland)
- Michael Decker (University of Wurzburg, Germany)
- Sandrine Ongeri (BioCIS, Université Paris Sud, France)
- Sophie Faure (ICCF, Université Clermont Auvergne, France)
- Ludovic Jean (COBRA, Université de Rouen Normandie, France)
Awards: The best oral communications/posters will receive an award allowing young scientists in attending international meetings.
Individual career sessions: Individual one-hour meetings will be organized with representatives of human resource managers from major pharmaceutical firms as well as from start-ups (simulated job interviews, recommendations to present appropriately CV...).
Registration fees: 50 euros - Low cost rooms (50 euros for 2 nights) are also available.
All information on: http://www.sct-asso.fr/yrfm.html
NEWS FROM THE BIOLOGICAL AND MEDICINAL CHEMISTRY SECTOR (BMCS) OF THE ROYAL SOCIETY OF CHEMISTRY (RSC)
The BMCS is pleased to announce some upcoming events.
ANGLO-SWISS SYMPOSIUM: USING CHEMICAL BIOLOGY TO IDENTIFY NEW TARGETS FOR MEDICINAL CHEMISTRY
4th February 2020, PharmaCenter, Basel, Switzerland
The call for poster abstracts will close 13th January 2020
Synopsis: Experts in chemical biology and medicinal chemistry come to the scientific hub of Basel for a symposium featuring 8 speakers and a poster session. Exciting science is promised, as well as great networking opportunities.
2nd RSC/SCI APPLIED LATE STAGE FUNCTIONALISATION SYMPOSIUM
18th to 19th February 2020, University of Manchester, Manchester, UK
Synopsis: The meeting will highlight some of the hot and emerging developments in the inorganic catalysis and biocatalysis arenas and both the academic and application of late-stage functionalisation methodologies.
6th RSC/SCI SYMPOSIUM ON ION CHANNELS AS THERAPEUTIC TARGETS
24th to 25th February 2020, Wellcome Genome Campus Conference Centre, Cambridge, UK
Synopsis: The symposium will showcase the most recent advances in ion channel science and promote scientific interaction between scientists with a shared interest in the field of ion channel drug discovery. The conference will be organised around series of plenary lectures delivered by international leaders in ion channels science and drug discovery from academia and industry
1st RSC BMCS SYNTHESIS IN DRUG DISCOVERY AND DEVELOPMENT SYMPOSIUM
27th March 2020, Eli Lilly, Windlesham, Surrey, UK
The call for poster abstracts will close on 30th January 2020
Synopsis: This symposium aims to highlight and celebrate the crucial role which synthetic organic chemistry plays in the success of small molecule drug discovery. The three main themes of the symposium will be:
• Innovative synthesis facilitating candidate discovery
• Novel bioisosteres and methodology applicable to drug discovery
• Overcoming challenges of scale-up and process scale chemistry
31st SYMPOSIUM ON MEDICINAL CHEMISTRY IN EASTERN ENGLAND
30th April 2020, Hatfield, UK
The call for abstracts will close on 20th December 2019
Synopsis: The Symposium on Medicinal Chemistry in Eastern England, known colloquially as the "Hatfield MedChem" meeting, is a highly successful, long-standing, one-day meeting which runs annually. The scientific program will comprise presentations showcasing medicinal chemistry case studies from tools to candidates, across a range of modalities, therapeutic areas and target classes, as well as covering more general topics from the forefront of drug discovery of relevance to medicinal chemists. The meeting aims to be informal and interactive and the event will offer excellent scientific and networking opportunities for all those working in medicinal chemistry and drug discovery.
5th RSC / DMDG / DMG NEW PERSPECTIVES IN DMPK
5th to 6th May 2020, Liverpool, UK
The call for abstracts for Oral presentation will close on 20th December 2019
Synopsis: Members from across the DMPK research community are encouraged to join colleagues from across academic, industrial, and third-sector institutions and contribute to the ongoing discussion, evolution and application of DMPK in various scenarios.
The event programme will incorporate sessions themed around the following key topics:
- DMPK and Drug Discovery
- DMPK and Drug Safety
- Analytical and Computational Advances in DMPK
In addition, the programme also includes a keynote talk, ‘flash’ presentations from early career researchers, and opportunities for open debate and discussion.
KINASE 2020: 9th RSC / SCI SYMPOSIUM ON KINASE INHIBITOR DESIGN
1st to 2nd June 2020, London, UK
The call for abstracts for Oral presentation will close on 18th December 2019
Synopsis: With more than 49 FDA-approved small molecules, the field of kinase inhibition continues to attract significant investment from the drug discovery and development community. The 9th RSC/SCI symposium on kinases will encompass plenary lectures on emergent topics and case studies of ongoing programmes as well as successful past programmes. A range of topics including new screening approaches, brain penetrant kinase inhibitors, induced protein degradation, allosteric inhibitors and kinase inhibition for immuno-oncology will be covered, along with views and perspectives on the future of kinase inhibitor research.
EFMC-ISMC 2020: REGISTRATIONS ARE OPEN!
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EFMC SPONSORED EVENTS
January 19-23, 2020
St. Anton, Austria
2nd Alpine Winter Conference on Medicinal and Synthetic Chemistry
January 22-24, 2020
International Symposium on Chemical Biology
February 4, 2020
2nd Anglo-Swiss Symposium 2020 - Using Chemical Biology to identify new targets for Medicinal Chemistry
February 18-19, 2020
Manchester, United Kingdom
Applied Late Stage Functionalisation: Where Chemistry Meets Biology
February 24-25, 2020
Cambridge, United Kingdom
6th RSC / SCI Ion Channels as Therapeutic Targets Symposium
March 23-24, 2020
Eindhoven, The Netherlands
50 years of Medicinal Chemistry and Chemical Biology
March 27, 2020
Surrey, United Kingdom
Synthesis in Drug Discovery and Development
April 14-15, 2020
San Francisco, United States
Medicinal Chemistry Strategies to Mitigate Preclinical Safety Risks in Drug Discovery
EFMC ORGANISED EVENTS
May 17-20, 2020
Oegstgeest, The Netherlands
16th EFMC Short Course on Medicinal Chemistry: New Opportunities in GPCR Drug Discovery
September 6-10, 2020
EFMC-ISMC 2020: XXVI EFMC International Symposium on Medicinal Chemistry
September 10-11, 2020
EFMC-YMCS 2020: 7th EFMC Young Medicinal Chemist Symposium
Postdoctoral researcher, Medicinal Chemistry, University of Antwerp, Pharmaceutical Sciences, Antwerp, Belgium