XXVII EFMC INTERNATIONAL SYMPOSIUM ON MEDICINAL CHEMISTRY (EFMC-ISMC 2022) – CALL FOR ABSTRACTS
The XXVll EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2022) is organised by the Société de Chimie Thérapeutique (SCT), on behalf of the European Federation for Medicinal Chemistry and Chemical Biology (EFMC).
The event will take place in Nice, France on September 4-8, 2022. The organisers are confidently planning for a presential event, with hybrid options if the situation would require it. Access to the conference will be limited to fully vaccinated individuals.
Calendar of Abstract Submissions
- Deadline for Oral Communication submission and free Poster submission: March 24, 2022
- Announcement of accepted oral communications: mid-May, 2022
After March 24, 2022 and until June 23, 2022, abstracts for Posters can still be submitted, but with a handling fee of 50,00€
The 2022 programme will cover advances in drug discovery in major therapeutic areas, including bacterial and viral infections, with a particular attention to current and emerging viral pandemics, but also neurodegenerative and cardiovascular diseases, rare diseases, and cancer. EFMC-ISMC 2022 will also feature most recent advances in new technologies such as the exploitation of RNA as drug target, artificial intelligence in drug discovery, natural products-based drug discovery, DNA encoded libraries applications and the development of covalent drugs, PROTACs and molecular glues. Innovative approaches in medicinal chemistry will be included such as the development of immunomodulating compounds or the application of affinity selection – mass spectrometry for drug discovery.
In a series of dedicated sessions, the interface between chemical biology and drug discovery will be highlighted, including topics such as in vivo chemistry for target discovery and validation, molecular imaging, and photochemical approaches. Finally, particular emphasis will again be put on first time disclosures and recent highlights in medicinal chemistry.
More information and registration on www.efmc-ismc.org.
Share the news on social media with the #EFMC_ISMC.
10th EFMC-YSN MEDCHEMBIOONLINE | WHAT CAN THE MEDICINAL CHEMISTS LEARN FROM DATA SCIENCES?
In its 10th edition of the now renowned MedChemBioOnline series, the EFMC Young Scientists Network join forced with the EFMC Computational Chemistry Initiative to offer an exciting programme around “What Can the Medicinal Chemists Learn from Data Sciences?”
The event will take place on February 24 between 17:00 and 19:15 CET. Have a look at the programme:
- Data Science in Medicinal Chemistry: Evolution or Revolution?
Dr Nikolaus Stiefl (Novartis, Switzerland)
- Data Science, AI, ML and Drug Discovery: Symeres' Point of View
Dr Rutger Folmer (Symeres, The Netherlands)
- Practical Cheminformatics with Open Source Software
Dr Pat Walters (Relay Therapeutics, United States)
- Round Table Discussion: "What Can the Medicinal Chemists Learn from Data Sciences?"
Dr Zoe Cournia (Biomedical Research Foundation, Academy of Athens, Greece)
Dr Natalja Kurbatova (Zifo RnD Solutions, Switzerland)
Dr Nikolaus Stiefl (Novartis, Switzerland)
Dr Pat Walters (Relay Therapeutics, United States)
Dr Rutger Folmer (Symeres, The Netherlands)
More info and registration on www.medchembio.online.
Interested in becoming the exclusive sponsor of the event? Reach out to us at firstname.lastname@example.org.
The “literature spotlight” section of the newsletter will bring you a summary of recently published research in a concise and accessible way. Multiple thematics from different journals will be highlighted thanks to the valuable contribution of members of the EFMC working groups.
This contribution will focus on the recently published article on “Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity” (by Victoria G. Klein et al. in Journal of Medicinal Chemistry)
For decades, small organic molecules able to inhibit or modulate biological targets have been the main approach use in drug discovery. This traditional approach was focused on targets with well-defined catalytic pockets that suit the accommodation of small molecules. Many proteins, however, do not fulfil these requirements and they have been considered as “undruggable”. An alternative strategy to overcome these limitations is the employment of chimeric molecules called Proteolysis Targeting Chimeras (PROTACs). PROTACs are heterobifunctional molecules that degrade rather than inhibit the target proteins. These chimeric molecules are typically formed by a protein-of-interest (POI)-targeting ligand and a ligand that binds to an E3 ligase connected by a linker. PROTACs induce the formation of a ternary complex between the POI and E3 ligase, that leads to the polyubiquitination and subsequent targeted degradation of the POI.
While PROTACs present several advantages due to their novel mechanism of action, their bifunctional nature endows them with a higher size than the warhead ligands on which they are based. This makes PROTAC compounds go beyond the “Rule of 5” and can impose hurdles to their pharmaceutical development. An important pharmacokinetic difficulty for high-molecular-weight compounds is their permeability. In this context, Victoria G. Klein et al. hypothesize that is possible to improve PROTACs degradation activities, by increasing their permeability.
In a first place, in order to validate this proof of concept, the authors performed a model compound “Liposcan”. For this purpose, they synthesized a set of seven VHL-based “PROTAC-like” compounds, with different warheads in order to vary their lipophilicities (ALog P) from 1.2 to 6.0. After studying their membrane permeability using the parallel artificial membrane permeability assay (PAMPA), they determined that the permeabilities of the model compounds increased with ALog P up to an ALog P of around 4. Above this value, permeability decreased as ALog P increased.
In a second step, Victoria G. Klein et al. mentioned that in addition to lipophilicity, the number of hydrogen bond donors (HBDs) in compounds is a crucial determinant of permeability. Therefore, they created a new set of compounds with an amide-to-ester. This second set of ester-containing, liposcan compounds presented a similarly broad ALog P range of 1.9−6.6. After evaluating their membrane permeabilities, the authors determined that over an ALog P range of 1−4, amide-to-ester substitutions increase permeability for several linker types. Furthermore, the esters maintained plasma stability and binding to the E3 ligase.
Finally, the authors applied the insights from these model compounds to two previously published BET-targeting PROTACs, MZ1 and ARV-771. They showed that the correct combination of an amide-to-ester substitution and ALog P modulation dramatically increased the membrane permeability. Further, these modified compounds presented an increased ability to degrade BET proteins and induce cytotoxicity, while maintaining both stable ternary complex formation and plasma stability
All in all, the authors showed the usage of a systematic investigation of linker lengths and lipophilicity combined with amide-to-ester substitutions to improve the permeability of heretobifunctional molecules. The study demonstrated that PROTACs achieve the highest permeability at moderate lipophilicities (3−5), and that, inside this range, increasing the lipophilicity of a compound leads to increased permeability. Further, they also demonstrated that amide-to-ester substitutions can increase PROTAC permeability. Consequently, ester-containing compounds are likely to have better pharmaco- kinetic properties than amide compounds. Finally, even if esters are more prone to hydrolysis, and thus less stable in plasma, the authors claim that adding bulky substituents in the surrounding area drastically reduces compound degradation in plasma. Consequently, amide to ester substitution appears a viable option for PROTAC pharmacokinetic improvement.
Victoria G. Klein, Adam G. Bond, Conner Craigon, R. Scott Lokey, and Alessio Ciulli “Amide-to-Ester Substitution as a Strategy for Optimizing PROTAC Permeability and Cellular Activity” Journal of Medicinal Chemistry Article ASAP DOI: 10.1021/acs.jmedchem.1c01496
EFMC-YSN MENTORING PROGRAMME 2022 – APPLICATIONS ARE OPEN
To inspire, connect and provide opportunities to medicinal chemists and chemical biologists in their Early Career, the Young Scientists Network of the EFMC is hosting the second edition of the mentoring programme, aiming to connect motivated students with high-profile mentors.
The mentoring programme is shaped for PhDs (up to 18 months before the end PhD) and Post-docs, who are seeking a career in medicinal chemistry, chemical biology or related fields, either in industry or academia. The main objective is to support their transition into the job market by providing feedback, soft-skill training, and overall guidance.
More information and mentee application on www.efmc.info/mentoring-programme.
Deadline for application is March 1, 2022.
Want to join the programme as a mentor? Reach out to us at email@example.com.
2022 IUPAC-RICHTER PRIZE AWARDED TO MICHAEL E. JUNG
Michael E. Jung, Head of the Department of Chemistry and Biochemistry at UCLA, has been awarded the 2022 IUPAC-Richter Prize in recognition of his research, which has afforded new drugs for the treatment of advanced prostate cancer.
The acceptance lecture will be held in New York, NY, USA (June 26-29, 2022) at the 37th ACS National Medicinal Chemistry Symposium and he will present a second lecture at the XXVII EFMC International Symposium on Medicinal Chemistry in Nice, France (Sept. 4-8, 2022).
This year marks the ninth occasion of the IUPAC-Richter Prize, which was established in 2005 by the IUPAC (International Union of Pure and Applied Chemistry) and Richter PLC. Awarded biannually, the awardee is announced by the IUPAC following nominations and the decision of an indepedent international selection committee. According to the rules of the prize, the awardee is expected to give two lectures, one in Europe and one in the United States, at international symposia on medicinal chemistry. The lecture in which the prize is awarded occurs alternatively in Europe and in the United States. The awardee receives an award of $10,000, which is sponsored by Richter PLC, and a plaque, which is presented by IUPAC.
The previous awardees are: 2006: Malcolm FG Stevens (UK), 2008: Jan Heeres (Belgium), 2010: Arun Ghosh (USA), 2012: Stephen Hanessian (Canada), 2014: Helmut Buschmann (Germany), 2016: Michael Sofia (USA), 2018: Peter Grootenhuis (USA) and 2020: John Macor (USA).
EFMC GRANTS 2022 – APPLICATIONS ARE OPEN
EFMC is funding grants for EFMC organised events with the aim to support the participation of young academic scientists. Upon application, a limited number of grants will be covered by EFMC, corresponding to:
- Ten grants covering the full registration fees for the XXVII EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC 2022) and the 9th EFMC Young Medicinal Chemists' Symposium (EFMC-YMCS 2022).
- One grant covering up to 50% of the registration fees for the 16th EFMC Short Course on Medicinal Chemistry: New Opportunities in GPCR Drug Discovery (EFMC Short Course).
To apply for an EFMC grant, please fill in the application form and upload your CV, publication list, abstract, motivation letter, and support letter from the supervisor.
More information, deadlines, and application on www.efmc.info/ysn-grants
GET TO KNOW KOEN AUGUSTYNS (UNIVERSITY OF ANTWERP, BELGIUM)
In this edition, our #Iamamedicinalchemist was President of the EFMC from 2015 to 2018, and recently recognised an EFMC Honorary Fellow: Prof. Koen Augustyns (University of Antwerp, Belgium).
Get to know him better by reading the interview below:
How did you get interested in Medicinal Chemistry?
I am trained as a pharmacist and obtained my Masters in pharmaceutical sciences in 1988. During my six months internship, I realized that, although working in a community pharmacy is an important job with a big social impact, I wanted to do something else with my life. I was attracted to research, and mostly to the chemical aspects of medicines. However, during our studies, the chemical aspects of medicines were mostly focused on the analytical aspects. Around that time, Piet Wigerinck, former CSO of Galapagos, who graduated one year before me convinced me to have a talk with his supervisor, Prof. Piet Herdewijn. Piet Herdewijn was a young professor starting up his group in medicinal chemistry and he could easily convince me to join his group. In fact, I was his second PhD student.
Where and when did you obtain your PhD diploma?
After four years of PhD at the Rega Institute of KULeuven in Belgium, I obtained my diploma in 1992 with Prof. Piet Herdewijn as supervisor. The Rega Institute is best known for its research on infectious diseases. That period was marked by the HIV/AIDS pandemic and the discovery of the very first nucleoside and non-nucleoside reverse transcriptase inhibitors. The medicinal chemistry group collaborated intensively with the virology group lead by Prof. Erik De Clercq, and so this was a highly interesting and stimulating environment for me. The first paper I co-authored was published in Journal of Medicinal Chemistry in 1990 on the synthesis and anti-HIV activity of 2’,3’-dideoxyribo-5-chloropyrimidine analogues. This is more than thirty years ago. Time flies.
What was the topic of your PhD project?
The period of my PhD was also the start of chemically modified antisense oligonucleotides and the early days of automated DNA synthesis. We started exploiting the extensive knowledge of nucleoside chemistry available in the group to synthesize sugar-modified DNA analogues. I synthesized several hexopyranosyl nucleoside analogues that were functionalized for automated oligonucleotide synthesis and studied their properties such as hybridization specificity and enzymatic stability. My PhD thesis was entitled: Synthesis of sugar-modified antisense oligonucleotides. It is rewarding to notice that after 30 years of huge efforts the therapeutic principle of antisense oligonucleotides is finally paying off. At the end of 2016, Nusinersen was approved for the treatment of spinal muscular atrophy (SMA).
An interesting story connected to my PhD topic is that one day my supervisor came into my lab and told me that he heard that competition had increased “a little bit”. Around the same time, the group of Albert Eschenmoser at the ETH in Zurich also started investigating the synthesis of hexose nucleic acids. His purpose was to find why nature had chosen for pentose and not hexose nucleic acids. Finally we published almost together in 1992 our findings.
Where did you have your postdoc position?
After my PhD, I belonged to one of the last classes in Belgium that still had to do military service. Next, I went as a postdoc to the medicinal chemistry research group of Prof. Achiel Haemers at the University of Antwerp, Belgium. Soon, I realized that an international experience would be beneficial and applied in Germany for the prestigious international postdoctoral fellowships of the Alexander Von Humboldt Foundation. I was lucky to be selected and worked for one year under the supervision of Prof. Günther Jung at the University of Tübingen in Germany. This was a very rewarding experience. It was the start of combinatorial chemistry and Günther Jung was translating his experience in solid-phase peptide synthesis to applications in combinatorial chemistry. Four years ago, a large group of his PhD students and Postdocs celebrated his 80th birthday with a big party in Tübingen.
Where are you currently working and what is your current position?
Currently I am full professor of medicinal chemistry at the University of Antwerp in Belgium. Next to that I am also the Dean of the faculty of the university and until the end of 2019 I served the European Federation for Medicinal Chemistry in several roles.
What are your current research interests?
One of the major research lines in my group is the discovery of inhibitors of novel types of regulated cell death (ferroptosis and necroptosis) and their application in different animal disease models. Currently, I am also involved as medicinal chemist in a large collaboration financed by the EU-IMI programme to discover novel drugs to treat infections caused by mycobacteria. We are targeting both multiresistant tuberculosis (RespiriTB) as well as infections caused by non-tuberculous mycobacteria (RespiriNTM). Next to that, I am also interested in applications of biorthogonal chemistry for bioimaging and irreversible serine protease inhibitors as chemical tool compounds.
How would you explain what your research area is to non-scientists?
That is a very good point. Science communication to the general public that is paying for our research is extremely important. I indeed often get the question from non-scientists what I am doing the whole day. I usually start by explaining that a university professor has two main tasks: teaching and scientific research. And I add that because of that we don’t have as much holidays as the students. I try to explain that medicinal chemistry deals with the chemistry of medicines and that we make novel molecules that eventually one day can become a drug. The general public also needs to understand that discovering new drugs is a very time- and labour intensive process, but that even small steps that learn us what is the relation between the chemical structure and the therapeutic activity, how a molecule works at the molecular level and how this can influence a disease is important for the field. Nowadays, people more easily understand what Covid-19 is and how detrimental an infectious disease can be. They see the importance of having treatment and prevention options and the need to prepare for a next pandemic. I try to explain them that resistance to existing antibiotics is becoming a major threat and that untreatable bacterial infections is one of the next big challenges.
What do you like best about your work?
In medicinal chemistry, you design and create something new for the benefit of human health. This is in contrast to many other scientific disciplines where you analyse already existing things. I still remember the excitement during my PhD when you synthesize your first molecule that until then never existed on earth before.
What kind of tasks does your work involve?
Currently I am not working in the lab anymore. Next to teaching, an important task is to find money for research by writing national and international grant applications. Successful execution of these research projects is only possible by recruiting highly talented PhD students and postdocs and then guide them towards the research goals. More and more, research is done in multidisciplinary consortia so collaborative skills and networking are highly important as well. As a dean of the faculty, I am furthermore responsible for research policy, personnel and students, and administration. Luckily the latter is limited because I am fortunate to have a very efficient dean’s office. By far the most important task as a dean is to attract bright and motivated young professors.
What do you consider your greatest achievement in your scientific career?
It is difficult to name one. During my PhD we were among the first to incorporate sugar-modified nucleosides into oligonucleotides. As a young professor we pioneered the field of DPP4 inhibitors, which is now a well validated target with several inhibitors on the market as antidiabetic medicines. More recently we published several cell death inhibitors, among which the most potent ferroptosis inhibitors with interesting properties in in vivo disease models. I also felt very honoured to have served the European Federation for Medicinal Chemistry (EFMC) as an executive board member for 11 years, being the president from 2015 until the end of 2017.
Which of your papers are you most proud of and why?
One of my first papers. Augustyns, K. et al. Incorporation of Hexose Nucleoside Analogues Into Oligonucleotides - Synthesis, Base-Pairing Properties and Enzymatic Stability. Nucleic Acids Research 1992, 20, 4711-4716.
How many PhD students and postdocs do you currently supervise? Are you currently looking for a new PhD student or a postdoc?
I am the head of the research group of Medicinal Chemistry at the University of Antwerp (UAMC) that consists of around 25 researchers. I am directly supervising 3 PhD students and 9 postdocs. Currently we are not recruiting, but we had several open positions in the last two years.
What are the features of a successful PhD student or postdoc?
Of course you should have an excellent knowledge of organic and medicinal chemistry, but even more important is passion for science, ambition and the desire to obtain as much experience as you can through international mobility.
What was your first EFMC experience?
My first EFMC experience must have been as a young postdoc at the International Symposium on Medicinal Chemistry (EFMC-ISMC) in 1994 in Paris. I still remember this as an overwhelming and enthusing experience. As a young scientist I had never imagined to be one day also on stage in front of such a large group of medicinal chemists. In 2002 we decided to restart the Medicinal and Bioorganic Chemistry Division of the Royal Flemish Chemical Society (KVCV). One of the first things we did was to contact Edmond Differding, who was at that time the president of the Medicinal Chemistry Division of SRC, the chemical society of the French speaking part of Belgium. He stimulated us to apply for EFMC membership and in 2004 at the council meeting we were approved and I became EFMC council member. In 2009, when Gerhard Ecker became EFMC President, he asked me to apply for Secretary. That was the start of a 11-year long exciting journey in the executive committee of EFMC with among others the organisation of EFMC-ISMC in 2010 in Brussels and the Frontiers in Medicinal Chemistry symposium in 2015 in Antwerp.
What are your recommendations for a book, podcast, website, blog, YouTube channel or film?
“Breaking Bad”, although I do not recommend anyone to perform the chemistry that Walter White is doing.
Which scientist do you admire the most and why?
Paul Janssen, one of the pioneers of medicinal chemistry and drug discovery. He really brought our field to where we are now and he was and still is an inspiration to many scientists in Belgium and around the world.
Have you experienced any unfair situations during your scientific career?
No. On the contrary, I am very grateful for all the chances that I got and I am most thankful to all my collaborators
Which field of medicinal chemistry do you consider the most promising for the future?
The challenges in the field of infectious diseases are enormous. Not only we need more and better antivirals but we also badly need novel antibiotics to treat infections caused by multiresistant bacteria.
How do you see the future role of EFMC?
As a scientific federation EFMC has to bring people together around excellent science. In a scientific discipline such as ours that is highly dependent on multidisciplinary collaborations this will always remain an important objective for the future of medicinal chemistry and chemical biology.
MEDICINAL CHEMISTRY, CHEMICAL BIOLOGY, THE DANISH CHEMICAL SOCIETY, AND EFMC
Medicinal chemistry has traditionally had a strong presence in Denmark, with several pharmaceutical companies founded there that still operate with headquarters in the country. However, Denmark is also a small country, with a limited critical mass of practitioners of medicinal chemistry, which for many years led to the field of medicinal chemistry being part of the Danish Society for Toxicology, Pharmacology, and Medicinal Chemistry. Eventually, it became apparent that medicinal chemistry members had limited shared interests with the other two fields within the society and a process to start a new society was initiated.
During this process, two fundamental changes were determined to be important for the field. First, it was contemplated whether the field of medicinal chemistry in Denmark had more in common with the field of chemistry and, secondly, it was decided that activities in chemical biology are sufficiently related that this area should be included in a new constellation as well. As a result of these considerations, the Danish Society for Medicinal Chemistry and Chemical Biology was founded in 2017 with a board of people representing the largest universities in the country as well as members from industry.
The new society was accepted as a division under the Danish Chemical Society and became the Danish national society member of the EFMC. In this regard, one of the society’s annual activities is organizing a young investigator symposium to select the Danish participant in the EFMC Young Medicinal Chemist’s Symposium.
Interestingly, the decision to include chemical biology in this Danish society turned out to align perfectly with the recent developments within the EFMC. For additional thoughts regarding the chemical biology–medicinal chemistry continuum, please see ChemBioChem, 2021, 22, 2823.
#MEDCHEMCASES - SEMINAR BY THE DIVISION OF MEDICINAL CHEMISTRY OF THE GERMAN CHEMICAL SOCIETY (GDCH)
The MedChem Division of the German Chemical Society (GDCh) would like to invite you to the next #MedChemCASES online seminar which will be held on February 23 by Dr David Thaisrivongs (MSD).
The topic of the webinar will be “Synthetic Macrocyclic Peptides that Target Protein-protein Interactions: The Discovery and Early Chemistry Development of a PCSK9 Inhibitor”
Inhibition of Proprotein Convertase Subtilisin/Kexin type-9 (PCSK9) improves cardiovascular outcomes in patients requiring additional low-density lipoprotein cholesterol reduction on top of statins, but there has been limited uptake of the two commercialized PCSK9 antibody inhibitors due in part to cost and route of administration. The protein-protein interaction between PCSK9 and the low-density lipoprotein receptor which is targeted by these therapies is a large, flat surface, which has made the discovery of orally-bioavailable small molecule inhibitors highly challenging.
This talk will introduce the use of macrocyclic peptides to interrupt such protein-protein interactions and describe the discovery and early chemistry development of such a PCSK9 inhibitor.
Register for free here: https://us06web.zoom.us/webinar/register/WN_Domf-mL5Tg-E3LyD3pr0Fg
#GDCh (MedChem Division), #NextGenMedChem.
NEWS FROM THE DIVISION OF MEDICINAL CHEMISTRY OF THE GERMAN CHEMICAL SOCIETY (GDCH)
The German Chemical Society (GDCh) and the German Pharmaceutical Society (DPhG) cordially invite you to attend the annual meeting on "Frontiers in Medicinal Chemistry", which will be held online on March 13 -16, 2022.
The international symposium will focus on current developments, novel approaches and cutting-edge technologies in the field of medicinal chemistry and drug research with sessions on: Non-Mainstream Chemotypes, Chemical Epigenetics, First Disclosures & Case Studies, Next Generation Drugs, Macrocycles, AI – Retrosynthesis and Automation, Medicinal Chemistry and Target Highlights, Young Investigators.
The scientific program will include lectures, and poster presentations. It is the goal of the organisers to make this meeting an event of scientific excellence, attractive to both industrial and academic scientists in Medicinal Chemistry, Chemical Biology, and related fields of research.
More information and registration available here.
NEWS FROM THE BIOLOGICAL AND MEDICINAL CHEMISTRY SECTOR (BMCS) OF THE ROYAL SOCIETY OF CHEMISTRY (RSC)
The BMCS is pleased to announces some upcoming events:
- 5th RSC/DMDG/DMG New Perspectives in DMPK
- 8th RSC-BMCS Fragment-Based Drug Discovery Meeting
- 33rd Medicinal Chemistry in Eastern England (Hatfield Symposium)
5th RSC / DMDG / DMG New Perspectives in DMPK
22nd and 23rd February 2022, Liverpool, UK
Last chance to register
Synopsis: Members from across the DMPK research community are encouraged to join colleagues from across academic, industrial, and third-sector institutions and contribute to the ongoing discussion, evolution and application of DMPK in various scenarios
Fragments VIII: 8th RSC-BMCS Fragment-based Drug Discovery meeting
27thand 28th March 2022, Churchill College, Cambridge
Delegate Registration and Exhibitor/Sponsor registration is now open
Synopsis: The aim of the meeting is to continue the focus on case studies in Fragment-based Drug Discovery that have delivered compounds to late stage medicinal chemistry, preclinical or clinical programmes. Over three-quarters of the presentations will be focused on case studies
33rd Medicinal Chemistry in Eastern England (Hatfield symposium)
28th April 2022, The Fielder Centre, Hatfield, UK
Synopsis: Known colloquially as the "Hatfield MedChem" meeting, this a highly successful, long-standing, one-day meeting which runs annually. The scientific program will comprise presentations showcasing medicinal chemistry case studies from tools to candidates, across a range of modalities, therapeutic areas and target classes, as well as covering more general topics from the forefront of drug discovery of relevance to medicinal chemists
THIS NEWSLETTER IS KINDLY SPONSORED BY
ISSUE SPONSORED BY
Selvita is an integrated service company providing multidisciplinary support in resolving the unique challenges of drug discovery. Selvita offers the full range of support starting from target validation up to the selection of clinical candidates, including medicinal chemistry, in vitro and in vivo pharmacology, structural biology, ADME, pharmacokinetics and toxicology.
EFMC ORGANISED EVENTS
February 24, 2022
10th EFMC-YSN MedChemBioOnline
What Can the Medicinal Chemists Learn from Data Sciences?
May 8-11, 2022
Oegstgeest, The Netherlands
16th EFMC Short Course on Medicinal Chemistry New Opportunities in GPCR Drug Discovery
September 4-8, 2022
XXVll EFMC International Symposium on Medicinal Chemistry
September 8-9, 2022
9th EFMC Young Medicinal Chemists' Symposium
EFMC SPONSORED EVENTS
May 16-20, 2022
5th Russian Conference on Medicinal Chemistry
Postponed to June 19-22, 2022
Santiago de Compostela, Spain
XX National Meeting of the Spanish Society of Medicinal Chemistry
Postponed to July 27-29, 2022
3rd Molecules Medicinal Chemistry Symposium (MMCS): Shaping Medicinal Chemistry for the New Decade
Junior Research professor in chemical biology – medicinal chemistry, University of Antwerp, medicinal chemistry – pharmaceutical sciences,
PhD position for an organic chemist with an interest for drug discovery and proteomics, Technical University of Munich, TUM School of Life Sciences, Freising, GERMANY
Medicinal Chemist, SpiroChem AG, Chemistry, Basel, SWITZERLAND