13th EFMC SHORT COURSE ON MEDICINAL CHEMISTRY, Oegstgeest (near Leiden), The Netherlands - April 23-26, 2017
In 2009, EFMC launched a series of short courses aimed to favour cultural and scientific growth of the medicinal chemistry community. The theme in the 2017 issue will be "A Matter of Time; A Kinetic Perspective on Drug-Target Interactions".
The details of the complex formed between a drug molecule and its protein target is of key importance for in vivo drug efficacy. Most efforts in early drug discovery focus on optimization of drug-receptor interactions, such as target affinity and selectivity, whilst minimizing potential adverse ADMET effects. However, novel approaches are necessary in early drug discovery for optimal drug design and improved therapy, as attrition rates in clinical trials are disappointingly high.
Recently, the kinetics of a ligand-target interaction, such as the residence time of a small molecule on its protein target, are seen as increasingly important for in vivo efficacy and safety. However, the prospective use of this novel concept in medicinal chemistry and drug design has taken long to emerge.
Hence, the 13th EFMC Short Course on Medicinal Chemistry will provide a firm conceptual framework for the study of target binding kinetics. The focus of this course will be centred on all aspects of target binding kinetics, where renowned international experts in the field will highlight the concept and development of different kinetic binding assays, specific protein target interactions, impact of drug rebinding and PK/PD modelling.
Moreover, an industrial view on the importance, value and positioning of binding kinetics in drug discovery projects will be given. For this purpose, tutorials and real life examples will assist the participants in the short course to grasp not only a basic understanding but also to bring home inspiring case studies from both an academic and industrial perspective.
- Ad IJZERMAN (Leiden University, The Netherlands)
- Laura H. HEITMAN (Leiden University, The Netherlands)
- Henk TIMMERMAN (VU University Amsterdam, The Netherlands)
- Prof. Helena DANIELSON (UPPSALA UNIVERSITY, Sweden)
- Dr Liesbeth DE LANGE (UNIVERSITY OF LEIDEN, The Netherlands)
- Mr Wilbert DE WITTE (UNIVERSITY OF LEIDEN, The Netherlands)
- Dr Matthias FRECH (MERCK, Germany)
- Dr Laura HEITMAN (UNIVERSITY OF LEIDEN, The Netherlands)
- Prof. Ad P. IJZERMAN (UNIVERSITY OF LEIDEN, The Netherlands)
- Prof. Georges VAUQUELIN (VUB, Belgium)
Find out more about the speakers.
More information and registration form can be found on www.efmcshortcourses.org
CALL FOR NOMINATIONS - EFMC PRIZES 2017
To acknowledge and recognise an outstanding young medicinal chemist (≤ 12 years after PhD) working in industry or in academia within Europe, EFMC established the EFMC Prize for a Young Medicinal Chemist in Industry and the EFMC Prize for a Young Medicinal Chemist in Academia.
The Prizes consists of a diploma, € 1.000 and an invitation for a short presentation at the VII EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17), August 27-31, 2017, Vienna (Austria).
Deadline for Nominations/Applications: January 31, 2017
Find out more
NEWS FROM THE BIOLOGICAL AND MEDICINAL CHEMISTRY SECTOR (BMCS) OF THE ROYAL SOCIETY OF CHEMISTRY (RSC)
Exciting Symposia for your 2017 diary:
- 6th RSC-BMCS Fragment-based Drug Discovery meeting (5th-7th March 2017, ParkHotel, Schönbrunn, Vienna, Austria)
- 2nd Transporters in Drug Discovery and Development (15th-16th May 2017, RSC at Burlington House, London, UK)
- RSC Anglo-Nordic MedChem symposium (12th-14th June 2017, Hotel Comwell Borupgaard, Snekkersten, Denmark)
Abstract deadlines are approaching fast, so come along and present your research:
6th RSC-BMCS Fragment-based Drug Discovery meeting (5th-7th March 2017, ParkHotel, Schönbrunn, Vienna, Austria)
Call for poster abstracts closes on 21st December
Synopsis: The aim of this meeting will be to continue the focus on case studies in Fragment-based Drug Discovery that have delivered compounds to late stage medicinal chemistry, preclinical or clinical programmes. The conference will include successful examples from all types of fragment-based approaches, including high concentration, NMR, SPR and X-ray screening.
2nd Transporters in Drug Discovery and Development (15th-16th May 2017, RSC at Burlington House, London, UK)
Call for oral abstracts closes on 30th November
Synopsis: Cell surface transporters play a key role in human health and disease, both through their impact on drug disposition and as therapeutic targets in their own right. This meeting should be of interest to medicinal chemists, DMPK scientists and other workers with interests on the impact of transporters on human health.
RSC Anglo-Nordic MedChem symposium (12th-14th June 2017, Hotel Comwell Borupgaard, Snekkersten, Denmark)
The call for oral abstracts closes on 31st January
Synopsis: The scientific programme will feature classical and contemporary themed lectures, focusing on medicinal chemistry and related technologies and disciplines across a range of drug targets and modalities. A distinguishing feature of this symposium is the collegiate conference style which encourages an atmosphere of information sharing and learning.
NEWS FROM THE FRENCH SOCIETY OF THERAPEUTIC CHEMISTRY (SCT)
The French Society Of Therapeutic Chemistry (SCT) is pleased to announce the 24th Young Research Fellow Meeting (24èmes Journées Jeunes Chercheurs) that will take place in Paris, France (Faculty of Pharmacy Paris-Sud) – February 8-10, 2017. This 24th edition will gather 250 young participants from Europe.
This meeting brings together young European scientists (PhD students, post-doctoral fellows and young academic/industrial confirmed researchers) and gives them the opportunity to present and discuss the latest innovations and future trends in Medicinal Chemistry.
The topics presented cover all aspects of research in medicinal chemistry: structure-activity relationship studies, ADMET, imaging, drug vectorization, nanotechnologies, natural products, synthetic methodology, etc…
We are delighted and honored to have world-class medicinal chemists as speakers:
- Maria Laura Bolognesi (Italy)
- Karl Gademann (Switzerland)
- Jean-Pierre Vors (France)
- Matthew Fuchter (UK)
- María Luz López Rodríguez (Spain)
- Daniel Rauh (Germany)
The meeting will offer:
- Many prestigious prizes (SCT, ACS, EFMC), attributed for best oral communications and posters.
- 25 oral communications selected from abstracts
- 30 Flash Poster Presentations selected from abstracts
- Poster sessions
- Individual career sessions
ISSUE SPONSORED BY
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Medicinal / Synthetic Organic Chemists, Concept Life Sciences: Drug Discovery, Sandwich, Kent, United Kingdom
MsC student or PhD internship, KU Leuven: Cellular and Molecular Medicine, Leuven, Belgium
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