MedChemWatch
Monthly Newsletter October 2017

UPCOMING EVENT: MEDCHEM 2017 - ANNUAL ONE-DAY MEETING ON MEDICINAL CHEMISTRY OF KVCV & SRC

MedChem 2017, with six invited lectures and three oral communications, will be held on Friday December 1, 2017, in Leuven. The title and focus of the symposium will be “The Many Pharmacotherapeutic Faces of Nucleosides and Oligonucleotides”.

The objective of the one-day symposium is to delve into the latest developments of the applications of nucleosides, nucleotides and nucleic acids in medicinal chemistry. The applications where situated in the past mainly in the fields of antivirals, anticancer compounds and antisense oligonucleotides. More recently, new therapeutic applications in for example immune-oncology, and the discovery of new functions of nucleic acids in the cell such as siRNA, Crispr/Cas  together with new breakthroughs in in vitro selection technologies (XNA aptamers), have revived the field and have opened many new possibilities  for drug design. The present knowledge in these different research areas will be presented during the symposium.

For more information on the symposium, please visit the regularly updated website: www.medchem.be

JOIN THE EFMC COMMUNICATION TEAM!

The European Federation for Medicinal Chemistry (EFMC) invites young and motivated medicinal chemists or chemical biologists to volunteer for its communication team, to help develop, feed and monitor its presence on social media (Twitter, LinkedIn & Facebook).

This is an opportunity for you to be informed of the latest scientific trends and events, develop an extensive network across the community, strongly increase your visibility and awareness of the many opportunities offered by the EFMC… and it comes with a travel grant to the EFMC main symposium!

The members of the EFMC communication team are responsible for the execution of a professional and relevant social media content, and to develop a plan to boost community engagement and EFMC brand awareness. The social media strategy will be elaborated with the EFMC executive committee.

What can you contribute?

  • Help develop and implement the social media and content strategy, to extend the EFMC social media presence and engage the community.
  • Contribute to the editorial calendar.
  • Develop a strategy for social listening and community engagement in order to join and drive the conversation on various social media platforms.
  • Collaborate with experts in the community to create the contents of original tweets and posts.

Interested in joining the team?

Contact the EFMC Administrative Secretariat with your CV and a motivation letter, by November 1, 2017: administration@efmc.info

THE EFMC SUPPORTS EUCHEMSí POSITION PAPER: RESEARCH AND EDUCATION WITHOUT BORDERS AFTER BREXIT

Having the objective of advancing the science of medicinal chemistry by promoting cooperation and networking, the EFMC supports EuCheMS’ Position Paper pleading for a continued, post-Brexit, collaboration between the European Union and the United Kingdom on research and education without boarder.

The Position Paper was singed on behalf of the EFMC by Dr Yves Auberson, President-Elect.

Read the Position Paper

THE PERSPECTIVE ARTICLE FROM THE EFMC WORKING GROUP ON MEDICINAL CHEMISTRY AND CHEMICAL BIOLOGY IS FREELY AVAILABLE FOR A FEW DAYS

"Joining Forces: The Chemical Biology–Medicinal Chemistry Continuum" is freely available until November 10, using the link below.

Read the full paper

EFMC COUNCIL MEETING 2017

The Annual Council Meeting of the EFMC took place in Vienna on August 26-27, in connection with the EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry.

The Council Meeting is a forum for the exchange of information between the representatives of the National Adhering Organisations and the Executive Committee. It is also the place where the main decisions on EFMC activities are taken via democratic debate and voting. Finally, it also provides an excellent opportunity for the EFMC delegates to build pan-European networks

Top row – from left to right

Roberto Di Santo, Gabriele Costantino (Council Member, Italy), Andrew Abell (Observer from the Asian Federation for Medicinal Chemistry), Thierry Langer (Council Member, Austria), Sharon Bryant (Candidate EC Member 2018-19), Koen Augustyns (EFMC President), Sergey Bachurin (Council Member, Russia), Yves Auberson (EFMC President Elect), Emmanuel Mikros (Council Member, Greece), Antoni Torrens (EC Member), Pascal George (EFMC Treasurer), Rui Moreira (EC Member), Pilar Goya Laza (Council Member, Spain & EuCheMS), Matthew Tozer (EC Member), Vesna Gabelica Markovi (Council Member, Croatia), Anders Karlén (EFMC Secretary), Georg Jaeschke (Council Member, Switzerland), Katarzyna Kiec-Kononowicz (Council Member, Poland), Karl-Heinz Baringhaus (Delegate GDCh, Germany), Trond Ulven (Council Member, Denmark), Jarkko Rautio (Council Member, Finland).

Below row – from left to right

Janos Fischer (Observer from the IUPAC), Bernd Clement (Council Member, DPhG, Germany), Danijel Kikelj (Council Member, Slovenia), Janos Sapi (Council Member, France), Annika Jenmalm Jensen (Council Member, Sweden), Peter Molenveld (Council Member, The Netherlands), Laurent Provins (Council Member, SRC, Belgium), Dave Alker (Council Member, UK), Serge Van Calenbergh (Council Member, KVCV, Belgium), Matilde Marques (Council Member, Portugal), Ayla Balkan (Council Member, Turkey).

Absentees

Gunars Duburs (Council Member, Latvia), Miroslav Gasic (Council Member, Serbia), Henk Timmerman (EFMC Advisor), Franz Von Nussbaum (Council Member, GDCh - Germany), Janos Wölfling (Council Member, Hungary), Eylon Yavin (Council Member, Israel).

NEWS FROM THE SECTION OF MEDICINAL/PHARMACEUTICAL CHEMISTRY OF THE CROATIAN CHEMICAL SOCIETY

Report of the 10th JMMC:

The 10th Joint Meeting on Medicinal Chemistry was organized by the Medicinal and Pharmaceutical Chemistry Section of the Croatian Chemical Society in collaboration with eight European national medicinal chemistry societies (Austria, Czech Republic, Greece, Hungary, Italy, Poland, Slovakia and Slovenia). It was held on June 25–28, 2017 in Dubrovnik (Srebreno), one of the most prominent tourist and conference destinations in the Croatia and the Mediterranean.

The 10th JMMC continued the tradition and covered drug discovery advances in the major therapeutic areas, including anti-infectives, neurodegenerative diseases and oncology. The JMMC 2017 presented various topics which covered advances in approaches for hit finding and accelerating lead optimization process, exploration of new chemical entities from nature, discovery of small molecule chemical probes, optimization of drug delivery, and computational medicinal chemistry. The main intention was to get together in a relaxed atmosphere scientists from different countries, disciplines and sectors to discuss results and challenges associated with new drug discovery.

The majority of the lecturers came from the nine countries whose Medicinal Chemical Societies participated in organization of JMMC meetings. However, three eminent scientists were invited as additional plenary lectures. The inaugural plenary lecture was delivered by Prof. Nenad Ban who opened the event with an interesting talk, entitled Beyond the Prokaryotic Ribosome: Structural and Functional Insights Into Eukaryotic and Mitochondrial Ribosomes in which he presented the latest results in the research of the structure and function of eukaryotic and mitochondrial ribosomes (Figure 1). Prof. Gerhard Klebe got lots of attention with the excellent lecture: What Thermodynamics Can Help to Understand Protein-Ligand Binding in Medicinal Chemistry. The field of epigenetic science was presented by Paul Brennan and his lecture Chemical Probes in Target Discovery.

The scientific programme comprised eleven plenary lectures, fifteen keynote lectures, sixteen oral communications and 172 poster presentations (http://www.jmmc2017.hr/index.php). Out of almost 200 posters, three young scientists were awarded with a certificate for the best poster presentation and the gift package from our media partner ChemMedChem, a Wiley-VCH and ChemPubSoc Europe journal specializing in traditional medicinal chemistry and nanomedicine. This was an EFMC sponsored event, which helped in gathering a sigificant number of scientists.

JMMC 2017 was supplemented with a rich social programme in one of the most popular congress and vacation resorts in Croatia. We are pleased that many students participated in this event which allowed young scientists to meet established medicinal chemists for an exciting exchange of ideas.

In summary, the 10th Joint Meeting on Medicinal Chemistry in Dubrovnik 2017 was a scientifically and socially very rewarding event, providing an opportunity for more than 250 participants from 30 countries worldwide for the exchange of scientific information and for establishing personal contacts. At the end, the members of the organizing committee wish a successful organisation to our successors for the 11th JMMC, which will takes place in Prague in 2019.

Figure 1. Prof. dr.sc. Nenad Ban (ETH Zurich, Switzerland)

Figure 2. Prof. dr. sc. Gerhard Klebe (University of Marburg, Germany)

 

Figure 3&4. Sightseeing of Dubrovnik

NEWS FROM THE FRENCH MEDICINAL CHEMISTRY SOCIETY (SCT)

To promote excellence, and also to support young researchers at the start of their careers, the French Medicinal Chemistry Society (“Société de Chimie Thérapeutique”, S.C.T.) provides each year a prestigious prize entitled “Prix d’Encouragement à la Recherche en Chimie Thérapeutique”, sponsored by “Institut de Recherche Servier”, awarded to one or several young scientists.

The prize of 3,000 euros (divided between the laureates) includes an invitation to give a lecture during the upcoming "XXVth Young Research Fellows Meeting" (Orléans, March, 5-7th 2018).

Your application should be submitted by e-mail before November, 1st 2017!

Please visit the website www.sct-asso.fr for more details and regulations about this award.

NEWS FROM THE SPANISH MEDICINAL CHEMISTRY SOCIETY (SEQT)

The SEQT is pleased to announce the following meeting:

XVIII SEQT National Meeting “New Perspectives in Drug Discovery”
January 23-26, 2018, Salamanca, Spain

The Spanish Society of Medicinal Chemistry (SEQT) has the pleasure to invite you to join the XVII SEQT National Meeting. The meeting will be held in the Faculty of Pharmacy of the University of Salamanca, Spain, on January 23-26 2018.

The scientific program will include plenary and invited lectures, short oral communications and flash poster presentations, covering the main stages of modern drug discovery. It will be complemented by a commercial exhibition and enjoyable social program.

The University of Salamanca is the oldest university in Spain. In 2018, the eighth centenary of its foundation will be commemorated (centenario.usal.es) with a great variety of scientific and other cultural events. Among them, the 18th SEQT National Meeting will give attendees the opportunity to participate in this remarkable celebration.

Provisional programme is shown in our web site https://congresoseqt2018.usal.es

Deadline for registration: 31st October 2017

For further information and regular updates, please visit our website https://congresoseqt2018.usal.es

NEWS FROM THE BIOLOGICAL AND MEDICINAL CHEMISTRY SECTOR (BMCS) OF THE ROYAL SOCIETY OF CHEMISTRY (RSC)

The BMCS is pleased to announce the opening of the nominations for the 2018 Capps Green Zomaya Award, and the following meetings:

2nd RSC / SCI Fibrosis Medicinal Chemistry Conference
November 10, 2017, SCI, London, UK

Recent Trends and Technologies in Medicinal Chemistry towards Medicines of the Future
December 8, 2017, Society for Medicines Research, London, UK

Capps Green Zomaya Award 2018

Closing date for nominations 31st October 2017

Nominations are open for the 2018 Capps Green Zomaya Award. This Award was founded in 2002 in memory of the chemists Nigel Capps, Richard Green and Alex Zomaya to recognise outstanding contributions to medicinal or computational medicinal chemistry.

The Award was established by Celltech, GlaxoSmithKline, NicOx and Vernalis, and is now independently administered by the Biological and Medicinal Chemicals Sector (BMCS) of the RSC in conjunction with the Capps Green Zomaya Trust.

Winners of the award receive £2000, a certificate and a medal and traditionally are invited to give the Capps Green Zomaya Memorial lecture at the East of England Medicinal Chemistry Symposium held in April each year.

For more information and guidelines for nomination see the BMCS website http://www.rsc.org/ScienceAndTechnology/Awards/CappsGreenZoyama/index.asp

 

2nd RSC / SCI Fibrosis Medicinal Chemistry Conference
November 10, 2017, SCI, London, UK

Website:  http://www.rsc.org/events/detail/27671/2nd-sci-rsc-fibrosis-medicinal-chemistry-symposium

Fibrosis disease is the result of a dysregulated wound healing process and is responsible for considerable patient mortality affecting multiple organs in diseases such as idiopathic pulmonary fibrosis (IPF), diabetic nephropathy, steatohepatitis and systemic sclerosis. Fibrosis disease pathology is often complex and this inaugural symposium on fibrosis will provide mechanistic insight and progress in medicinal chemistry and drug discovery from experts across the world.

Recent Trends and Technologies in Medicinal Chemistry towards Medicines of the Future
December 8, 2017, Society for Medicines Research, London, UK

Website:  http://www.rsc.org/events/detail/27399/recent-trends-and-technologies-in-medicinal-chemistry-towards-medicines-of-the-future

This one day symposium will highlight some of the new technologies and research trends at the forefront of drug discovery today through an expert speaker cohort of scientists from Pharma, biotech, academia, public sector and charitable institutions from across the UK.

NEWS FROM THE DIVISION OF MEDICINAL CHEMISTRY AND CHEMICAL BIOLOGY (DMCCB) OF THE SWISS CHEMICAL SOCIETY (SCS):

The Swiss Chemical Society (SCS) and the Contact group for research matters (KGF) are proud and happy to announce the winners of the KGF-SCS Industrial Investigator Awards 2017 and to honor their outstanding achievements. The award lectures have taken place on the occasion of the SCS Fall Meeting in Bern on August 21-22, 2017.

The KGF-SCS Senior Industrial Science Award (CHF 10’000)

is given to

Dr. Emmanuel Pinard, F. Hoffmann-La Roche Ltd, Basel,

for his very successful research on several therapeutic targets as enzymes (Bace1, COMT), ion channels (NMDA), GPCRs (Orexin, Vasopressin) and transporters (GlyT1) that address high unmet central nervous system disorders such as Parkinson’s Disease, Stroke, Schizophrenia, Depression, Autism and Spinal Motor Atrophy.

and to

Dr. Thomas Netscher, DSM Nutritional Products, Ltd, Kaiseraugst

for his achievements in advancing synthetic methodology and total synthesis of natural products, specifically vitamins and isoprenoid derived compounds.

  

The KGF-SCS Industrial Science Award (CHF 7’000)

is given to

Dr. Richard Sedrani, Novartis Pharma AG, Basel

for his achievements in many important projects as research chemists, team leader, project leader and unit head that resulted in the discovery and development of the mTOR inhibitor Everolimus, which is the active ingredient of several successfully marketed drugs: Certican® / Zortress®; Afinitor®, Xience™.

The latest edition of MedChemComm, the official journal of the EFMC, is available at:

MedChemComm

 

ISSUE SPONSORED BY


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EFMC ORGANISED EVENTS

September 6-7, 2018
Ljubljana, Slovenia
5th EFMC Young Medicinal Chemist Symposium (EFMC-YMCS 2018)

EFMC SPONSORED EVENTS

June 22, 2018
Madrid, Spain
V SEQT Young Researchers Symposium

June 27, 2018
Dublin, Ireland
2nd Medicinal Chemistry Ireland Conference

November 12-13, 2018
London, United Kingdom
2nd SCI/RSC Symposium on Antimicrobial Drug Discovery

EFMC ACCREDITED SCHOOL

EFMC SPONSORED SCHOOLS

September 19-21, 2018
Rimini, Italy
Summer School in Pharmaceutical Analysis (SSPA)

October 7-12, 2018
Leysin, Switzerland
13th Swiss Course on Medicinal Chemistry

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Medicinal / Synthetic Organic Chemists, Concept Life Sciences: Drug Discovery, Sandwich, Kent, United Kingdom

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