MedChemWatch
Monthly Newsletter November 2017

UPCOMING EVENT: 12TH NATIONAL ORGANIC CHEMISTRY MEETING (12ENQO) AND THE 5TH NATIONAL MEDICINAL CHEMISTRY MEETING (5ENQT) - Early registration and abstract submission deadline: November 15, 2017

In January 2018, the 12th National Organic Chemistry Meeting (12ENQO) and the 5th National Medicinal Chemistry Meeting (5ENQT) will take place in Coimbra, Portugal, jointly organised by The Divisions of Organic Chemistry and Medicinal Chemistry of the Portuguese Chemical Society (SPQ).

As in the previous edition of the Meeting, by bringing together in a single event these two important and complementary areas, new synergies are expected to arise. The interdisciplinary nature of this meeting will be reflected in an attractive programme comprising Plenary Sessions, Invited Communications, Oral Communications and Poster Communications that will surely attract the interest of a large audience. There will be plenty of time for casual discussions and exchanges of ideas among the participants.

Coimbra is a beautiful historical city in the middle of Portugal, whose historical city centre has been granted UNESCO World Cultural Heritage status. In Coimbra, we can find one of the oldest and most prestigious universities in Europe, whose students bring life and multiculturalism to the city. It is filled with amazing places, magnificent monuments and many unique traditions. Coimbra is easy to reach from both Lisbon and Porto international airports by train and bus.

The deadline for the reception of abstracts & Early-bird registration is November 15, 2017.

For more information please contact: 12enqo5enqt@chemistry.pt or visit http://12enqo5enqt.eventos.chemistry.pt/

UPCOMING EVENT: 18TH MEETING OF THE SPANISH SOCIETY OF MEDICINAL CHEMISTRY: “NEW PERSPECTIVES IN DRUG DISCOVERY” - Early registration deadline: November 15, 2017

The Spanish Society of Medicinal Chemistry (SEQT), member of the European Federation for Medicinal Chemistry (EFMC), welcomes you to the 18th meeting “New perspectives in drug discovery”, to be held in Salamanca on January 23-26, 2018.

This meeting is one of the many events programed to celebrate the 800 years of the University of Salamanca, the oldest university in Spain, founded in 1218. The organizing committee is honoured to warmly invite SEQT members to such an important celebration for our Studii Salamantini and our friendly city of Salamanca, which was declared UNESCO World Heritage Site in 1988.

The scientific program will include both plenary and invited lectures, as well as short oral communications and flash poster presentations, covering different aspects of drug discovery and development.

Early Registration: until November 15, 2017

For more information please contact: congresoseqt2018@usal.es or visit https://congresoseqt2018.usal.es/en/index.html

CALL FOR NOMINATIONS - EFMC 2018 AWARDS

To acknowledge outstanding achievements in the field of Medicinal Chemistry, EFMC confers every two years three Awards. The 2018 Awards will be presented at the XXV EFMC "International Symposium on Medicinal Chemistry" (EFMC-ISMC'18) to be held in Ljubljana, Slovenia on September 2-6, 2018.

All 3 awards consist of a diploma, € 7.500 and an invitation to give a headline presentation at EFMC-ISMC 2018.

For the advancement of Medicinal Chemistry and the development of international organisational structures in Medicinal Chemistry. The award will be given for outstanding achievements in the field of Medicinal Chemistry.

To acknowledge and recognise outstanding research in the field of Medicinal Chemistry in its broadest sense by a young scientist. This Award has been established with the support of UCB Pharma.

To encourage innovation and investigation in technological development related to drug discovery, this Award established with the support of Prous Institute will be given for the discovery, evaluation or use of new technologies.

Nominations for these Awards consist of a nomination letter, a brief CV including a list of selected publications and two supporting letters. Self-nominations are also accepted. The nominations should be submitted to Dr Yves Auberson, President of the EFMC as of 2018, via the following link:

Deadline for submission: January 31, 2018

CALL FOR NOMINATIONS - EFMC PRIZES 2018

To acknowledge and recognise outstanding young medicinal chemists (≤ 12 years after PhD) working in Europe, EFMC established the EFMC Prize for a Young Medicinal Chemist in Industry and the EFMC Prize for a Young Medicinal Chemist in Academia. The Prizes consists of a diploma, € 1.000 and an invitation for a short presentation at the XXV EFMC International Symposium on Medicinal Chemistry (EFMC-ISMC’18) in Ljubljana, Slovenia on September 2-6, 2018.

Deadline for Nominations/Applications: January 31, 2018

More information 

2018 IUPAC-RICHTER PRIZE – CALL FOR NOMINATIONS

IUPAC and Gedeon Richter, Plc. are pleased to announce the 2018 IUPAC-Richter Prize in Medicinal Chemistry. The Prize was established in 2006 by a generous gift from the Chemical Works of Gedeon Richter, Plc. (Budapest, Hungary) to acknowledge the key role that medicinal chemistry plays toward improving human health. The prize – USD 10000 – is to be awarded to an internationally recognised scientist, preferably a medicinal chemist, whose activities or published accounts have made an outstanding contribution to the practice of medicinal chemistry or to an outstanding example of new drug discovery.

The 2018 IUPAC-Richter Prize will be presented during the 36th National Medicinal Chemistry Symposium (29 April – 2 May 2018) on Medicinal Chemistry in Nashville, Tennessee (USA), where the recipient will also give a plenary lecture on the subject of his/her research.

Applications should be received by NOMINATION only, with just one person needing to serve in that capacity, although a total of five (5) individuals should be listed as referees. The package must be submitted electronically and should contain:

  • a complete resume
  • a professional autobiography of not more than two pages
  • a one-page summary of what the individual considers to be his/her activities, accomplishments and/or publications that have had the most significant impact upon the field of Medicinal Chemistry

The material will be forwarded confidentially to an independent selection committee appointed by the IUPAC Subcommittee on Drug Discovery and Development.

Nomination materials should be submitted by 15 December 2017 through this Nomination Form.

For further information please contact Professor Janos Fischer, Chair of the IUPAC Subcommittee on Drug Discovery and Drug Development, by email at j.fischer@richter.hu

NEWS FROM THE FRENCH MEDICINAL CHEMISTRY SOCIETY (SCT)

The SCT is pleased to announce the following meeting:

Chemical Biology, Contribution to Molecular Therapeutic Innovation: Conjugates and Drug Discovery Chemistry, new challenges for targeted therapies, December 7, 2017, Paris, France
Website: http://www.sct-asso.fr/fall_one_day_symposium.html

25th Young Research Fellows Meeting, March 5-7th, 2018, Orléans, France
Website: http://www.sct-asso.fr/yrfm.html

Chemical Biology, Contribution to Molecular Therapeutic Innovation: Conjugates and Drug Discovery Chemistry, new challenges for targeted therapies, December 7, 2017, Paris, France

The aim of the symposium is to illustrate the great potential and the applications of conjugates in contributing to therapeutic innovation.

This meeting is dedicated to a large audience of organic and medicinal chemists, biochemists and biologists, and covers recent advances in the field of conjugates for therapeutic approaches, focusing on their preparation, evaluation and applications.

Recent development of conjugates offers new promises for the treatment of various diseases. In oncology, two antibody-drug conjugates (brentuximab vedotin and trastuzumab emtansine) are already approved for clinical use, and numerous conjugates are still in clinical evaluation. In addition to antibodies, other classes of vehicles like proteins, peptides, vitamins and polymers have been investigated for the selective delivery of drugs to malignant tissues. Conjugates also emerge for the development of new vaccines or appear as powerful tools to explore or manipulate living systems in chemical biology approaches.

Learn more about the programme & Register!


25th Young Research Fellows Meeting, March 5-7th, 2018, Orléans, France

The YRFM Young Research Fellows Meeting is an initiative of the French Medicinal Chemistry Society (SCT). The 24th edition gathered 250 young participants from Europe. The 25th edition will take place at the University of Orléans (Hall Sully, department DEG, Law, Economics and Management).

This meeting brings together young European scientists (PhD students, post-doctoral fellows and young academic/industrial confirmed researchers) and gives them the opportunity to present and discuss the latest innovations and future trends in Medicinal Chemistry.

The topics presented cover all aspects of research in medicinal chemistry: the research and validation of biological targets of therapeutic interest, screening, design, optimization and selection of drug candidates, chemical biology, medicinal chemistry, pharmacokinetics, metabolism and toxicity (ADME-T: absorption, distribution, metabolism, excretion, toxicity).

REGISTER NOW for only €50!

Deadline for registration is January 8th, 2018.

NEWS FROM THE DIVISION MEDICINAL CHEMISTRY, ROYAL NETHERLANDS CHEMICAL SOCIETY (KNCV)

Prizes FIGON Dutch Medicines Days – delegate EFMC-YMCS 2018

During the FIGON Dutch Medicines Days, a two-day national symposium on drug development and medicines, the division Medicinal Chemistry of the Royal Netherlands Chemical Society awarded a presentation prize (€ 500) and poster prize (€ 250) to young researchers in medicinal chemistry.

The presentation prize was awarded to Anthe Janssen of the group of dr. Mario van der Stelt of the Leiden University for the talk entitled ‘Synthesis and biological evaluation of BIA 10-2474: an irreversible and aspecific FAAH inhibitor’. In his PhD study he investigated the FAAH inhibitor BIA 10-2474 that caused death of one volunteer in a phase 1 trial. By using activity-based proteomic methods he showed that the drug inhibits several lipases, which are not targeted by another clinically tested FAAH inhibitor. He will be the Dutch delegate for the EFMC-YMCS 2018 in Ljubljana, where he will present his results obtained in his PhD study.

The poster prize was awarded to Timo de Groof of the group of Martine Smit of the VU Free University Amsterdam for the poster entitled ‘Identification and characterization of nanobodies targeting HCMV-encoded US28’. In his PhD study he identified the first US28-targeting nanobodies by using a newly established nanobody platform.

NEWS FROM THE BIOLOGICAL AND MEDICINAL CHEMISTRY SECTOR (BMCS) OF THE ROYAL SOCIETY OF CHEMISTRY (RSC)

2017 Malcolm Campbell Award Announcement – Osimertinib Team

The Royal Society of Chemistry Biological and Medicinal Chemistry Sector is proud to announce the winners of the Malcolm Campbell Memorial Prize for 2017. The prize has been awarded to Sam Butterworth, Darren Cross, Ray Finlay, Richard A. Ward and Michael J. Waring for contributions to the team that discovered TAGRISSOTM (osimertinib, AZD9291) at AstraZeneca.

Osimertinib, a potent, oral, CNS-active, irreversible epidermal growth factor receptor (EGFR) inhibitor that was developed specifically for the treatment of patients with T790M mutation positive NSCLC, has demonstrated significant clinically meaningful improvement in efficacy compared to standard of care chemotherapy in these patients, with fewer serious adverse events.  In record time, just 2 years and 9 months after the first patient was dosed, osimertinib was provisionally approved for patients whose tumours have a specific epidermal growth factor receptor (EGFR) mutation (T790M) and whose disease has progressed due to resistance to other EGFR-blocking therapy

The BMCS Committee wishes to express its gratitude for the high-quality entries from both academia and industry for the 2017 award.

For more information see http://www.rsc.org/Membership/Networking/InterestGroups/BMCS/

The latest edition of MedChemComm, the official journal of the EFMC, is available at:

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EFMC ORGANISED EVENTS

September 6-7, 2018
Ljubljana, Slovenia
5th EFMC Young Medicinal Chemist Symposium (EFMC-YMCS 2018)

EFMC SPONSORED EVENTS

June 22, 2018
Madrid, Spain
V SEQT Young Researchers Symposium

June 27, 2018
Dublin, Ireland
2nd Medicinal Chemistry Ireland Conference

November 12-13, 2018
London, United Kingdom
2nd SCI/RSC Symposium on Antimicrobial Drug Discovery

EFMC ACCREDITED SCHOOL

EFMC SPONSORED SCHOOLS

September 19-21, 2018
Rimini, Italy
Summer School in Pharmaceutical Analysis (SSPA)

October 7-12, 2018
Leysin, Switzerland
13th Swiss Course on Medicinal Chemistry

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Medicinal / Synthetic Organic Chemists, Concept Life Sciences: Drug Discovery, Sandwich, Kent, United Kingdom

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MsC student or PhD internship, KU Leuven: Cellular and Molecular Medicine, Leuven, Belgium

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