Prestwick Chemical, Strasbourg-Illkirch, France, was created in 1999 by Prof. Camille-Georges Wermuth as a spin off from the University of Strasbourg and is now an established drug innovator. Last month, we expanded our capacities significantly, partnering with the Weesp (NL) based Pharma Plexus Holland BV, the former Dutch Abbott research site.
With our smart screening libraries and our integrated discovery services, we help our customers in the pharmaceutical, biotech, and cosmetics industry to identify and optimize new bio-active molecules. We have specialized in providing development candidates using competitive medicinal chemistry. Our scientists are supported by state-of the art computational tools. They apply technologies to build a strong foundation for the understanding of structure-activity relationships and for risk assessment based on cutting edge in silico ligand profiling.
Prestwick Chemical, with its partners, offers a complete coverage of early drug discovery steps from virtual screening to optimized leads, ready for preclinal development. Our services include model building, assay development, high-througphut and fragment screening, and medicinal chemistry at all stages from hit expansion up to lead optimization. In addition, we provide custom synthesis with scale-up potential, as well as exploratory chemistry and library design on an exclusive basis.
The highly experienced medicinal chemistry team has performed hit to lead and lead optimization campaigns towards all major target classes (enzymes such as kinases, receptors such as GPCRs, ion channels, and protein protein interfaces). Prestwick Chemical has devoted much effort to ensure that the medicinal chemists work on the most promising hit series: Our medicinal chemists evaluate the hit series with respect to IP space, emerging SAR, and chemical tractability. So far, we have produced more than 9000 original compounds, from which seven have already entered into clinical development: Two are currently in clinical phase III studies, two in phase II, and three have reached clinical phase I. Several more are currently in pre-clinical development.
The Prestwick Chemical compound collections (Prestwick Chemical Library®, Prestwick Phytochemical Library, and Prestwick Fragment Library) are of highest international standard, and validated worldwide by a large number of pharmaceutical companies and academic labs. We guarantee to provide re-supply of each compound, thus allowing customers to rapidly validate and follow-up with hits obtained.
Prestwick Chemical has several modular service offerings that can be used separately or combined, on a pure FTE based service model, or with risk and IP sharing. For further information on Prestwick Chemical, please visit the website at:
www.prestwickchemical.com
or send an email to
contact@prestwickchemical.fr
By Thierry Langer, CEO
