The European Federation for Medicinal Chemistry (EFMC) is an independent association representing medicinal chemistry societies in Europe. Its objective is to advance the science of medicinal chemistry by promoting cooperation and networking, by providing training and mentoring, by rewarding scientific excellence, and by facilitating communication and influencing stakeholders.

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ACSMEDI-EFMC: Medicinal Chemistry Frontiers 2017, June 25-28, 2017 - Discover the Final Scientific Programme.

The sixth edition of the conference intends again to bring scientists working in the medicinal chemistry field together in order to share new and exciting results. Check the final Scientific Programme.

The Scientific Program for Frontiers 2017 will feature sessions covering the latest advances in medicinal chemistry. Session topic areas include:

    Small Molecule Modulators of RNA
    Positive Allosteric Modulators
    Biased Agonism in GPCRs
    Targeting Regulated Cell Death
    Drug Discovery in Academia
    The Latest in Antivirals
    IO and Epigenetics in Treating Cancer

The programme will be complemented by a poster session, a commercial exhibition and a social programme. Poster presentations from postdoctoral and graduate students will be considered for two poster prizes, from J. Med. Chem. and ACS Med. Chem. Letters, in the amount of $200. Those selected will give a 10 minute talk on their poster during the Wednesday morning session.

Attractive lodging rates at the newly renovated venue (Downtown Sheraton, 17th Street Philadelphia) have been negociated by the organizers and can be booked on the accomodation page.

We hope to see you in Philadelphia in June 2017!


The 9 Oral Communications have been selected for the 7th edition of the EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17)

The Symposium Chairs - Erick Carreira (ETH Zurich, Switzerland) and Karin Briner (Novartis, United States) – have selected the 9 Oral Communications that will be given the opportunity to give a 15’ talk at the EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17) scheduled to take place in Vienna, Austria on 27-31 August, 2017.

The 9 selected oral communication are:

  • Development of Synthesis Strategies to Dna-Encoded Compound Libraries - of A Chemoresistant Sequence, and Micellar Nanoreactors - Dr Andreas Brunschweiger (TU Dortmund, Germany)
  • Expanding Screening Decks by Innovative MCR Scaffolds - Prof. Alexander Dömling (University Of Groningen, RUG, The Netherlands)
  • Chemically Induced Degradation of the Oncogenic Transcription Factor Bcl6 - Dr Peter Ettmayer (Boehringer-Ingelheim, Austria)
  • Stereoselective Peptide Modifications – Efficient Tools for Natural Product and Drug Synthesis - Prof. Uli Kazmaier (Saarland University, Germany)
  • Mimicking Nature Complexity With 3d-Fragments Assembly - Dr Hugues Lemoine (Edelris, France)
  • Discovery Of Ucb0942, The First Rationally Designed Antiepileptic Drug With a Dual Mechanism of Action for the Treatment of Drug-Resistant Epilepsy - Dr Laurent Provins (UCB, Belgium)
  • The Discovery of Soluble Guanylate Cyclase Stimulators for The Treatment of Pulmonary Arterial Hypertension - Dr Subharekha Raghavan (MSD, United States)
  • Discovery of Rg7314, A Vasopressin 1a Receptor Antagonist for the Treatment of Social Communication Deficits in Autism Spectrum Disorders - Dr Patrick Schnider (F. Hoffmann-La Roche, Switzerland)
  • Exploring New Methods for Facile Synthesis of Some Biologically Interesting Molecules - Prof. Ming-Hua Xu (Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences, China)

Click here to have a look at the full speakers’ list.

Registration to the EFMC-ASMC’17 is still possible and abstract submission for poster presentation is open until June 20 (subject to a prior payment of 50€ handling fee).


Report of the 13th EFMC Short Course: A matter of time; a kinetic perspective on drug-target interactions

‘How to use new insights into the kinetics of ligand – target interaction to improve the profile of the biological activities of your new compounds, thus making them better candidates for therapeutic use’ was the topic of the 13th EFMC short course held in the conference Centre "Oud Poelgeest" in the outskirts of the City of Science Leiden, from 23-26 April.

About 30 participants — mainly from European countries, but the Americas were also represented — followed a programme of lectures and discussions with expert scientists from Belgium, Germany, Sweden and the Netherlands. The beautiful scene of the venue, a small castle in a park full of flowers contributed to the relaxed and informal atmosphere during the course.

The programming was coordinated by Prof. Ad IJzerman and Dr Laura Heitman, both from the Leiden Academic Centre for Drug Research. The course was concluded by group discussions on the different sub-themes of the programme. The central question was ‘how will insight into the kinetics of the ligand - target interactions influence the outcome of the investigations in the different phases of the drug discovery.’ How does the kinetic behaviour of a compound when binding to the target, reflected by association (kon) and dissociation (koff) rate constants influence its selection for further development. This question was addressed for the process of target selection and validation, lead finding and optimization, and (pre) clinical development.

At the end of the programme the theme of the 2018 EFMC Short Course was announced as “Peptides and Proteins”.

The EC of the EFMC is very grateful to Ad IJzerman and Laura Heitman and all the lecturers who together made the 13th Short Course such a successful event.

Report by Henk Timmerman


The EFMC Grants to attend the ACSMEDI-EFMC Medicinal Chemistry Frontiers 2017 have been awarded:

Mr Luca Quattrini (University di Pisa, Italy); Mrs Josefa Zaldivar-Diez (Centro de Investigaciones Biologicas – CSIC, Spain) and Mrs Christina Tzitzoglaki (National and Kapodistrian University of Athens (UOA), Greece) covering the full registration fee to attend the upcoming ACSMEDI-EFMC Medicinal Chemistry Frontiers Meeting, Philadelphia, USA – June 25-28, 2017.

Every year, the EFMC is funding grants for its organised events with the aim to support the participation of young academic scientists. The full list of event, application conditions and application form can be found on the website www.efmc.info.
 


James E. Bradner will give the opening lecture at the upcoming EFMC-ASMC’17

James E. Bradner (President of the Novartis Institutes for BioMedical Research (NIBR), Cambridge, MA, United States) will give an inspiring talk on the Next-Generation Small Molecule Therapeutics as opening lecture of the upcoming 7th edition of the EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17) in Vienna, Austria, on August 28-31, 2017.

The symposium will bring together chemists from industry, academia and start-up companies from around the world and is focused on the most recent advances in new synthetic methodologies, total synthesis, fluorination approaches, bioisosteres and building blocks, chemical biology, medicinal chemistry, drug discovery and development leading to new or improved methods for the synthesis of pharmaceuticals. 

Beyond key lectures in synthetic and fluorination chemistry, as well as recent case studies in medicinal chemistry and drug discovery, the symposium aims at bridging the range from ‘small molecules’ to ‘large molecules’ including carbohydrates, natural products, novel protein scaffolds and genes; it is expected to attract experts in synthetic chemistry, medicinal chemistry, total synthesis, catalysis, drug discovery, molecular imaging, and chemical development.

The general concept of the meeting, with talks equally selected from industry and academia, will include an opening lecture, 26 invited lectures, 10 short communications selected from submitted abstracts and a large poster session and commercial exhibition.

Deadlines

  • April 10, 2017: Deadline for abstract submission for Oral Communication selection, free abstract submission for Poster presentation and Early Bird fees.
  • From April 10 until June 20, 2017: abstracts for Poster presentations can still be submitted, but are subject to the prior payment of 50,00€ handling fees.

Find out more on http://www.efmc-asmc.org


EFMC Prizes 2017

The Selection Committees are proud to announce the names of the winners and the runners-up of the EFMC Prize for a Young Medicinal Chemist in Industry and the EFMC Prize for a Young Medicinal Chemist in Academia.

EFMC PRIZE FOR A YOUNG MEDICINAL CHEMIST IN INDUSTRY

Philip Humphreys (GlaxoSmithKline, UK)
Fabien Lecomte (UCB, UK)
Mirjana Bukvic (Fidelta, Croatia)

EFMC PRIZE FOR A YOUNG MEDICINAL CHEMIST IN ACADEMIA

Christian Gruber (Medical University of Vienna, Austria)
Andreas Koeberlee (Friedrich-Schiller-University Jena, Germany)
Vittorio Limongelli (USI Lugano, Switzerland)

The EFMC Prizes Ceremony will take place during the 7th edition of the EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17) in Vienna, Austria, on August 28-31, 2017. Philip Humphreys and Christian Gruber will be invited to give an Oral Communication during the Symposium.


The EFMC Grant to attend the 13th EFMC Short Course has been awarded:

Mr Arun Kumar Mahato (University of Helsinki, Finland) has received the EFMC Grant, covering half of the registration fee, to attend the upcoming 13th EFMC Short Course on Medicinal Chemistry: A Matter of Time: A Kinetic Perspective on Drug-Target Interactions, Oegstgeest (near Leiden), The Netherlands - April 23-26, 2017.

Every year, the EFMC is funding grants for its organised events with the aim to support the participation of young academic scientists.

The upcoming event(s) where an EFMC Grant can be applied for are: 

  • EFMC-ASMC'17 - International Symposium on Advances in Synthetic and Medicinal Chemistry 
    (deadline for application is April 10, 2017
    ) - Link to the Event
  • 4th EFMC Young Medicinal Chemist Symposium 
    (in combination with the EFMC-ASMC'17)
     - Link to the Event

The full list of event, application conditions and application form can be found here


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