The European Federation for Medicinal Chemistry (EFMC) is an independent association representing medicinal chemistry societies in Europe. Its objective is to advance the science of medicinal chemistry by promoting cooperation and networking, by providing training and mentoring, by rewarding scientific excellence, and by facilitating communication and influencing stakeholders.

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EFMC-YMCS 2017: Oral Communications are announced

The programme of the 4th EFMC Young Medicinal Chemist Symposium will include 17 oral communications from promising young medicinal chemists. Out of the 17 oral communications, 13 of them will be given by prize winners from national young medicinal chemist meetings in Europe, and 4 of them have been selected from the 30+ submitted abstracts. 

The Oral Communications are: 

  • A Novel Hydantoin-Based Series of Dpre1 Inhibitors in M.Tuberculosis: Hit-to-Lead Optimization and Biological Profiling
    Ms Olga BALABON (UNIVERSITY OF ANTWERP, Belgium) 
  • Design and Synthesis of Functionalized Monocyclic 3-Amino-1-Carboxymethyl-Beta-Lactams as Potential Inhibitors of Penicillin Binding Proteins of Resistant Bacteria
    Ms Lena DECUYPER (GHENT UNIVERSITY, Belgium)
  • Molecular Recognition and Activation Mechanisms of Bitter Taste Receptors
    Dr Antonella DI PIZIO (THE HEBREW UNIVERSITY OF JERUSALEM, Israel
  • Modular Assembly of Reversible Multivalent Targeting Drug Conjugates 
    Mr Fábio Miguel FIGUEIREDO SANTOS (IMED.ULISBOA, Portugal)
  • Target Elucidation of Novel Trypanosomatid Inhibitors
    Mr Andrew FRASER (UNIVERSITY OF ST ANDREWS, United Kingdom)
  • The Catalytic Mechanism of The Iron-dependent Sulfoxide Synthase EgtB 
    Dr Kristina GONCHARENKO (UNIVERSITY OF BASEL, Switzerland)
  • Bicyclic Constrained Peptides Targeting the EGF-EGFR Interaction 
    Mr Salvador GUARDIOLA (INSTITUTE FOR RESEARCH IN BIOMEDICINE, Barcelona, Spain)
  • Exploring Hit-Identification Strategies for Energy-Coupling Factor Transporters, A Novel Target for the Development of Antibiotics 
    Prof. Anna K. H. HIRSCH (HELMHOLTZ INSTITUTE FOR PHARMACEUTICAL RESEARCH SAARLAND, Germany)
  • Development of Ligands for the Short-Chain Fatty Acid Receptor Ffa2 
    Mr Anders HOJGAARD HANSEN (UNIVERSITY OF SOUTHERN DENMARK, Denmark)
  • Development of Non-Covalent In Vivo Active Butyrylcholinesterase Inhibitors 
    Mr Urban KOSAK (UNIVERSITY OF LJUBLJANA, Slovenia)
  • Design, Synthesis and Biological Enaluation of New Artemisinin Hybrid Molecules 
    Mr Antonios S. LETIS (UNIVERSITY OF PATRAS, Greece)
  • Facing Non-Alcoholic Steatohepatitis with Multitarget Compounds
    Dr Daniel MERK (ETH ZÜRICH, Switzerland)
  • Fluorophore One-Atom-Controlled Recognition of DNA/RNA Secondary Structure
    Ms Tamara SMIDLEHNER (RUDER BOSKOVIC INSTITUTE, Croatia)
  • Discovery and Characterization of Novel Potent F508-Del Cftr Correctors
    Dr Federico SORANA (FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA, Italy)
  • The Role of The Sulfonyl Group on The Conformational Preferences Of Bis-Aromatic Compounds ¬ 5-Ht6 Receptor Antagonists and Beyond 
    Dr Jakub STARON (INSTITUTE OF PHARMACOLOGY, Poland)
  • Discovery and Optimization of Novel Inhibitors for the Ether Lipid-Generating Enzyme AGPS as Anticancer Agents 
    Dr Sergio VALENTE (SAPIENZA UNIVERSITY OF ROME, Rome, Italy)
  • In Situ Ugi Four-Component Reaction for the Protein-Templated Identification of Inhibitors of Endothiapepsin 
    Mr M. Yagiz ÜNVER (UNIVERSITY OF GRONINGEN, The Netherlands)
The symposium programme will also include 2 keynote lectures from Dr Christoph BOSS (IDORSIA PHARMACEUTICALS, Switzerland) and Dr Peter NUSSBAUMER (LEAD DISCOVERY CENTER, Germany).
 
Registration is still open, and the deadline to submit abstract for poster presentation is July 13! 
 
This year again, valuable prizes will be delivered to the best Oral Communication & best Poster selected by a jury, and to the best Presentation - voted by the public. More information on the Prizes can be found here.
 
Click here to Register and Submit your Abstract


The EFMC Grants to attend the EFMC-ASMC'17 have been awarded to:

  • Mrs Marta Barniol-Xicota (University of Barcelona, Spain)
  • Mrs Carolina Dos Santos Vinagreiro (University of Coimbra, Portugal)
  • Mrs Joanna Fedorowicz (Medical University of Gdansk, Poland)
  • Mr Markus Hartmann (Goethe University Frankfurt, Germany) 
  • Mrs Josa-Cullera Laia (University of Oxford, United Kingdom)
  • Mrs Giulia Rainoldi (Università degli Studi di Milano, Italy)
  • Mrs Silvia Serra (Université Paris Saclay, France)
  • Mrs Tamara Smidlehner (Ruer Boškovi Institute, Croatia)
  • Mr Steven Verlinden (Vrije Universieit Brussels, Belgium)

Covering the full registration fee to attend the upcoming EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC'17) and the 4th edition of the Young Medicinal Chemists Symposium (EFMC-YMCS 2017), Vienna, Austria – August 27-September 1, 2017.

Every year, the EFMC is funding grants for its organised events with the aim to support the participation of young academic scientists. The full list of event, application conditions and application form can be found on the website www.efmc.info.


Report of the 13th EFMC Short Course: A matter of time; a kinetic perspective on drug-target interactions

‘How to use new insights into the kinetics of ligand – target interaction to improve the profile of the biological activities of your new compounds, thus making them better candidates for therapeutic use’ was the topic of the 13th EFMC short course held in the conference Centre "Oud Poelgeest" in the outskirts of the City of Science Leiden, from 23-26 April.

About 30 participants — mainly from European countries, but the Americas were also represented — followed a programme of lectures and discussions with expert scientists from Belgium, Germany, Sweden and the Netherlands. The beautiful scene of the venue, a small castle in a park full of flowers contributed to the relaxed and informal atmosphere during the course.

The programming was coordinated by Prof. Ad IJzerman and Dr Laura Heitman, both from the Leiden Academic Centre for Drug Research. The course was concluded by group discussions on the different sub-themes of the programme. The central question was ‘how will insight into the kinetics of the ligand - target interactions influence the outcome of the investigations in the different phases of the drug discovery.’ How does the kinetic behaviour of a compound when binding to the target, reflected by association (kon) and dissociation (koff) rate constants influence its selection for further development. This question was addressed for the process of target selection and validation, lead finding and optimization, and (pre) clinical development.

At the end of the programme the theme of the 2018 EFMC Short Course was announced as “Peptides and Proteins”.

The EC of the EFMC is very grateful to Ad IJzerman and Laura Heitman and all the lecturers who together made the 13th Short Course such a successful event.

Report by Henk Timmerman


The EFMC Grants to attend the ACSMEDI-EFMC Medicinal Chemistry Frontiers 2017 have been awarded to:

Mr Luca Quattrini (University di Pisa, Italy); Mrs Josefa Zaldivar-Diez (Centro de Investigaciones Biologicas – CSIC, Spain) and Mrs Christina Tzitzoglaki (National and Kapodistrian University of Athens (UOA), Greece) covering the full registration fee to attend the upcoming ACSMEDI-EFMC Medicinal Chemistry Frontiers Meeting, Philadelphia, USA – June 25-28, 2017.

Every year, the EFMC is funding grants for its organised events with the aim to support the participation of young academic scientists. The full list of event, application conditions and application form can be found on the website www.efmc.info.
 


EFMC Prizes 2017

The Selection Committees are proud to announce the names of the winners and the runners-up of the EFMC Prize for a Young Medicinal Chemist in Industry and the EFMC Prize for a Young Medicinal Chemist in Academia.

EFMC PRIZE FOR A YOUNG MEDICINAL CHEMIST IN INDUSTRY

Philip Humphreys (GlaxoSmithKline, UK)
Fabien Lecomte (UCB, UK)
Mirjana Bukvic (Fidelta, Croatia)

EFMC PRIZE FOR A YOUNG MEDICINAL CHEMIST IN ACADEMIA

Christian Gruber (Medical University of Vienna, Austria)
Andreas Koeberlee (Friedrich-Schiller-University Jena, Germany)
Vittorio Limongelli (USI Lugano, Switzerland)

The EFMC Prizes Ceremony will take place during the 7th edition of the EFMC International Symposium on Advances in Synthetic and Medicinal Chemistry (EFMC-ASMC’17) in Vienna, Austria, on August 28-31, 2017. Philip Humphreys and Christian Gruber will be invited to give an Oral Communication during the Symposium.


The EFMC Grant to attend the 13th EFMC Short Course has been awarded:

Mr Arun Kumar Mahato (University of Helsinki, Finland) has received the EFMC Grant, covering half of the registration fee, to attend the upcoming 13th EFMC Short Course on Medicinal Chemistry: A Matter of Time: A Kinetic Perspective on Drug-Target Interactions, Oegstgeest (near Leiden), The Netherlands - April 23-26, 2017.

Every year, the EFMC is funding grants for its organised events with the aim to support the participation of young academic scientists.

The upcoming event(s) where an EFMC Grant can be applied for are: 

  • EFMC-ASMC'17 - International Symposium on Advances in Synthetic and Medicinal Chemistry 
    (deadline for application is April 10, 2017
    ) - Link to the Event
  • 4th EFMC Young Medicinal Chemist Symposium 
    (in combination with the EFMC-ASMC'17)
     - Link to the Event

The full list of event, application conditions and application form can be found here


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