Validating Chemical Probes

What are chemical probes and why are they important? Chemical probes are designed to selectively address a biological question; this is distinctly different from a drug, which is designed to produce a clinical outcome! Simple guidelines can be used to generate high-quality chemical probes and obtain reliable data to further our understanding of human biology and disease.

To select high-quality chemical tools, it’s important to understand the context of Hit Generation and Hit-to-Lead Optimization phases. These validated probes also play a crucial role in Phenotypic Drug Discovery campaigns and can support novel strategies like PROTAC design.

Please cite the EFMC Best Practices in Medicinal Chemistry WG work as following (please include both):

1. J. Quancard, B. Cox, D. Finsinger, S. M. Guéret, I. V. Hartung, H. F. Koolman, J. Messinger, G. Sbardella, S. Laufer, ChemMedChem 2020, 15, 2388. https://doi.org/10.1002/cmdc.202000597;
2. The material (webinars, slide decks and case studies) is freely accessible for personal use or for use in further training or teaching material from the EFMC website https://www.efmc.info/validating-chemical-probes