BMCS Conformational Design in Drug Discovery
EFMC Sponsored Event
Stevenage, United Kingdom
Conformational Design has played a key role in the medicinal chemistry of small molecule clinical candidates over the last 20 years. A key learning from multiple projects supported by experimental free ligand NMR solution conformations and protein-ligand X-ray structures is that the bioactive conformation of potent ligands is highly populated in solution. Ligand rigidification has been particularly successful in the design of selective and potent protein-protein interaction inhibitors and is becoming an increasingly important approach for PROTACs, molecular glues and other new modalities. This new RSC-BMCS event aims at building a community that shares conformational design strategies, technologies, and successful case studies. It will complement other rational drug design events and promote more successful research into future medicines.
Discover the programme here.
To register, please follow this link.
RNA Leaders Europe
Basel, Switzerland
RNA Leaders Europe is the #1 event focused on the development of mRNA, RNAi, ASOs, oligonucleotides, vaccines, microRNAs, genome editing, wider nucleic acids & RNA targets.
LSX are known for bringing life science investors together to assess and meet with the most promising up-and-coming biotech companies. When the first mRNA vaccines hit the market in 2020, one of our investors asked us to look at the resurgence of therapeutics targeting or made of RNA with the view to developing a high-level conference. And so, RNA Leaders was born.
The 2022 RNA Leaders Series saw 100+ world-class speakers and over 600+ senior leaders from around the world join the most comprehensive and only RNA industry-focused events in Europe (Basel) in the spring and the US (Boston) in the fall.
The community came together to hear the latest advances in RNA chemistry, get clinical updates from the companies developing new therapies, source the services partners who are helping to deliver drugs to patients and develop their network with over 750+ partnering meetings!
The explosion of the RNA field continues, and RNA medicines are at a critical moment in time. At first in wake of the pandemic mRNA vaccines dominated the headlines, although this is still the case mRNA therapeutics and vaccines to treat other infectious diseases and therapeutics like cancer are also taking centre stage.
Huge advances are also being made in RNAi and antisense technologies as our understanding of the chemistry evolves and AI platform progress discovery. Delivery tools are increasingly sophisticated and impactful. Advances in genomics and gene editing are driving new approaches. And exciting work targeting RNA with small molecules and non-linear RNAs are emerging.
With that in mind, we can’t wait to bring the community together, face-to-face, in spring 2024 for the third annual RNA Leaders Europe Congress.
8th RSC-BMCS Symposium on Mastering Medicinal Chemistry
EFMC Sponsored Event
London, United Kingdom
Mastering Medicinal Chemistry VIII is the latest in an ongoing series of conferences intended to provide expert advice and guidance to new practitioners in the field of drug discovery. It has been said that “there are two types of drug discovery programmes: those that hit serious problems and those that are going to hit serious problems”. Anticipating and preparing for such problems thus accelerates the delivery of new medicines: this event will feature presentations from experienced ‘drug-hunters’ in both industry and academia, who will talk about the challenges faced in modern drug discovery, and will share best practice common to all successful medicinal chemists.
Discover the programme here.
To register, please follow this link.
Annual Meeting on Frontiers in Medicinal Chemistry
Munich, Germany
The international symposium will focus on current developments, novel approaches and cutting-edge technologies in the field of medicinal chemistry and drug research with sessions on Case Studies & First Disclosures, Membrane Associated Targets, New and Bifunctional Drug Modalities, Deep Learning in Drug Design, New Synthetic Methods & MedChem Technologies, Neglected Diseases & Orphan Targets, Highlights in Medicinal Chemistry, Next Generation Drugs, and Young Investigators. The scientific program will include lectures, and poster presentations. It is the goal of the organizers to make this meeting an event of scientific excellence, attractive to both industrial and academic scientists in Medicinal Chemistry, Chemical Biology, Computer-Aided Drug Design and related fields of research.
Contact person : Dr. Gerhard Hessler - gerhard.hessler@sanofi.com
Contact at the University : Prof. Dr. Daniel Merk - daniel.merk@cup.lmu.de
- Division of Medicinal Chemistry of the German Chemical Society (GDCh) (Germany)
Webinar Covalent modalities -2: Covalent Drugs
Online Event
Since 2021, the French Medicinal Chemistry Society SCT organises or co-organises webinars. Webinars are a great virtual opportunity to engage and stimulate interactions within our community. They allow to share on technology, great science and best practices. SCT wishes to organize 3-4 webinars each year. Themes deal with up-to-date science and education in medicinal chemistry, chemical biology and all the subjects related to SCT’s mission.
Following our previous webinar on covalent modalities, focusing on probes in 2023, this webinar will propose case studies on covalent drugs and strategies.
Speakers
- Simona COTESTA, Novartis, Basel.
Identification and Optimization of a Novel Class of KRASG12C Inhibitors, Leading to the Discovery of JDQ443
- Chao ZHANG, University of Southern California, LA, USA.
Use of Latent Warheads for Covalent Drugging
- French Medicinal Chemistry Society (Société de Chimie Thérapeutique, SCT) (France)