Webinar: Novel Bicyclo[1.1.1]pentane (BCP) Fragments, their Roles, Preparation and the Challenges in Synthesis at Scale
Bicyclo[1.1.1]pentane (BCP) is emerging as an interesting fragment in medicinal chemistry. It serves as a bioisostere for a phenyl or tert-butyl group. Due to the SP3 hybridization of the structures, it is considered to generate drug-like molecules with good passive permeability, high aqueous solubility, and improved metabolic stability. BCP derivatives are already a pharmaceutically important scaffold. However, large scale preparation of BCP is still considered synthetically challenging. This webinar is going to review the medicinal application of the BCP in discovery new drug candidates, its metabolism and review new synthetic development to generate complex BCP derivatives in the recent literature. This webinar will be delivered by Dr Charles Chen from Bellen Chem who are kindly sponsoring this session.
For more information contact:
Molecular imaging is continuously expanding: it is increasingly being combined with advanced technologies such as artificial intelligence and has become a principal component of medical imaging. In the therapy field, targeted radiopharmaceuticals have been demonstrated to be effective and are increasingly used in a variety of clinical settings, often integrated with other therapeutic options. The ultimate goal is to design personalised, super-selective therapies and to identify more precise means of monitoring response to treatment in routine clinical practice.
In the last three years, the status of the EANM annual meeting as the world-reference congress in nuclear medicine has been confirmed. In order to maintain the high level of excellence, the 2019 EANM Congress will build on the traditions that are highly appreciated by all attendees, with the expansion of newer features. A specific educational track, implemented with the collaboration of the European School of Multimodality Imaging and Therapy, will include up-to-date teaching sessions, enriched pitfalls seminars and Continuous Medical Education interactive sessions. In all these active learning conferences, attendees will have the possibility to enhance their knowledge of multimodality imaging. A careful evaluation procedure relating to the speakers will be implemented in order to gain feedback and ensure that future interactive sessions continue to enjoy a positive response. With similar pedagogic intent, numerous multidisciplinary joint symposia, organised by several EANM Committees in collaboration with our sister societies, will offer an integrative approach to various topics relevant to the state of the art of our discipline.
For more information contact: email@example.com
One of the most difficult parts of discovering a drug is the optimization of pharmacokinetic properties. Drug hunters must be mindful of ADME (absoprtion, distribution, metabolism and excretion) properties to insure that drug candidates have adequate drug exposures across preclinical species and ultimately humans. Frequently, drug candidates are highly metabolized, limiting exposure to the drug target tissue. Thus, mitigation of metabolism issues is one of the most impactful ways to improve the pharmacokinetic profile of a drug candidate. This webinar will describe the most common drug metabolizing enzymes (DMEs) and metabolic pathways encountered in drug discovery. Importantly, it will also highlight the assays and mitigation strategies in use to profile, understand and optimize the metabolism of drug candidates. Other important principles, such as minimizing the formation of reactive metabolites and the impact of cytochrome p450 (CYP) inhibitors/activators on drug-drug interactions (DDIs) will also be described.
While the focus is on medicinal chemistry methods, this webinar will benefit all scientists who participate in the cross functional execution of drug discovery programs.
This FREE webinar will be presented by Dr Bryan Norman.
For more information contact: